Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6904193 | 0.84 | USP30 (0.33) | PDCD1CD274CHRNB2CHRNA4USP30 | |
| SCHEMBL5396601 | 0.84 | — | — | |
| SCHEMBL5396766 | 0.83 | — | — | |
| SCHEMBL5396417 | 0.83 | — | — | |
| SCHEMBL6329142 | 0.80 | ALDH1A1 (0.35) | ALDH1A1MAPK1CYP2A6HPGDHTR1A | |
| SCHEMBL5694274 | 0.79 | PDCD1 (0.37) | PDCD1CD274ALDH1A1MAPK1CHRNB2 | |
| SCHEMBL7525652 | 0.78 | PDCD1 (0.36) | PDCD1CD274ALDH1A1MAPK1CHRNB2 | |
| SCHEMBL28550963 | 0.78 | PDCD1 (0.36) | PDCD1CD274ALDH1A1MAPK1CHRNB2 | |
| SCHEMBL4603520 | 0.78 | PDCD1 (0.36) | PDCD1CD274ALDH1A1MAPK1CHRNB2 | |
| SCHEMBL7030356 | 0.78 | PDCD1 (0.36) | PDCD1CD274ALDH1A1MAPK1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844357-B2 | Substituted quinolin-2-one derivatives useful as antiproliferative agents | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |
| US-RE38683-E1 | Preparation of titanocenes | BOULDER SCIENTIFIC COMPANY (US) | 2005-01-04 | — | — | US | disclosed |
| US-20030166675-A1 | Substituted quinolin-2-one derivatives useful as antiproliferative agents | PFIZER INC. | 2003-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030166675-A1 | Substituted quinolin-2-one derivatives useful as antiproliferative agents | CCNA1, NRAS, CCNA2 | PDCD1 3173/4885CD274 4200/4885ALDH1A1 1191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.