Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | CAPN1 | P07384 | 5/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | CNKSR1 | Q969H4 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GHSR | Q92847 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7909167 | 0.85 | PFKFB3 (0.56) | PFKFB3RXFP1HPGDF2CAPN1 | |
| SCHEMBL7064175 | 0.80 | PFKFB3 (0.52) | PFKFB3RXFP1F2CAPN1MMP13 | |
| SCHEMBL29103412 | 0.80 | RXFP1 (0.53) | PFKFB3RXFP1HPGDF2CAPN1 | |
| SCHEMBL27181279 | 0.80 | RXFP1 (0.53) | PFKFB3RXFP1HPGDF2CAPN1 | |
| SCHEMBL6326184 | 0.80 | PFKFB3 (0.54) | PFKFB3RXFP1F2CAPN1CNKSR1 | |
| SCHEMBL27181275 | 0.80 | RXFP1 (0.53) | PFKFB3RXFP1HPGDF2CAPN1 | |
| SCHEMBL8213512 | 0.78 | RXFP1 (0.59) | PFKFB3RXFP1CAPN1MMP13CNKSR1 | |
| SCHEMBL14822899 | 0.78 | PFKFB3 (0.52) | PFKFB3RXFP1HPGDF2CAPN1 | |
| SCHEMBL13892314 | 0.78 | RXFP1 (0.55) | PFKFB3RXFP1CAPN1MMP13CNKSR1 | |
| SCHEMBL6329666 | 0.77 | PKM (0.55) | PFKFB3RXFP1F2CAPN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014840-A1 | Thiol sulfonamide metalloprotease inhibitors | PHARMACIA CORPORATION | 2005-01-20 | — | — | US | disclosed |
| US-6747027-B1 | SELECTIVELY INHIBITS IN VITRO ACTIVITY OF HUMAN MATRIX METALLOPROTEASE-13 OVER IN VITRO ACTIVITY OF HUMAN MATRIX METALLOPROTEASE-1 | PHARMACIA CORPORATION | 2004-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014840-A1 | Thiol sulfonamide metalloprotease inhibitors | MMP12, MMP13, MMP3 | PFKFB3 4076/4885RXFP1 3801/4885HPGD 420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.