Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6328906 | 0.82 | SCN9A (0.47) | GAAKDM4EALDH1A1GLAHPGD | |
| SCHEMBL11734758 | 0.74 | CASP6 (0.62) | KDM4EALDH1A1NPY5RNPY1RAPP | |
| SCHEMBL6336337 | 0.74 | SCN9A (0.48) | GAAKDM4EALDH1A1GLAHPGD | |
| SCHEMBL6330986 | 0.72 | ALDH1A1 (0.73) | GAAKDM4EALDH1A1GLAHPGD | |
| Hydrochloric Acid SCHEMBL6336714 | 0.71 | KDM4E (0.71) | GAAKDM4EALDH1A1GLAHPGD | |
| SCHEMBL5788193 | 0.71 | CYP1A2 (0.49) | KDM4EALDH1A1ADORA2ANPY5RMAPT | |
| SCHEMBL8893524 | 0.70 | NPY5R (0.70) | NPY5RNPY1RAPPAGTR1AGTR2 | |
| SCHEMBL6039582 | 0.70 | NPY5R (0.70) | NPY5RNPY1RAPPAGTR1AGTR2 | |
| SCHEMBL8892545 | 0.70 | NPY5R (0.70) | NPY5RNPY1RAPPAGTR1AGTR2 | |
| SCHEMBL8892633 | 0.69 | RAD52 (0.76) | KDM4EALDH1A1APPMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050096327-A1 | Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders | WARNER-LAMBERT COMPANY LLC | 2005-05-05 | — | — | US | claimed |
| US-20050096327-A1 | Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders | WARNER-LAMBERT COMPANY LLC | 2005-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096327-A1 | Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders | SLC6A2, SLC18A2, SLC6A3 | GAA 2064/4885KDM4E 1392/4885ALDH1A1 730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.