Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 1.00 |
| ▸ | TNF | P01375 | 6/20 | 1.00 |
| ▸ | MAPK13 | O15264 | 2/20 | 1.00 |
| ▸ | MAPK12 | P53778 | 2/20 | 1.00 |
| ▸ | MAPK11 | Q15759 | 2/20 | 1.00 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.91 |
| ▸ | CIT | O14578 | 1/20 | 0.91 |
| ▸ | MUSK | O15146 | 1/20 | 0.91 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.91 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.91 |
| ▸ | STK10 | O94804 | 1/20 | 0.91 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.91 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.91 |
| ▸ | ABL1 | P00519 | 1/20 | 0.91 |
| ▸ | EGFR | P00533 | 1/20 | 0.91 |
| ▸ | RAF1 | P04049 | 1/20 | 0.91 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.91 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.91 |
| ▸ | PRKCB | P05771 | 1/20 | 0.91 |
| ▸ | LCK | P06239 | 1/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doramapimod SCHEMBL129721 | 0.95 | MAPK14 (1.00) | MAPK14TNFMAPK13MAPK12MAPK11 | |
| Doramapimod SCHEMBL29353023 | 0.95 | MAPK14 (1.00) | MAPK14TNFMAPK13MAPK12MAPK11 | |
| SCHEMBL5967531 | 0.95 | MAPK14 (0.90) | MAPK14TNFMAPK13MAPK12MAPK11 | |
| Doramapimod SCHEMBL10320344 | 0.95 | MAPK14 (0.98) | MAPK14TNFMAPK13MAPK12MAPK11 | |
| SCHEMBL295792 | 0.94 | MAPK14 (0.89) | MAPK14TNFMAPK13MAPK12MAPK11 | |
| SCHEMBL29594033 | 0.94 | MAPK14 (0.89) | MAPK14TNFMAPK13MAPK12MAPK11 | |
| SCHEMBL13857350 | 0.94 | MAPK14 (0.89) | MAPK14TNFMAPK13MAPK12MAPK11 | |
| SCHEMBL5967529 | 0.93 | MAPK14 (0.87) | MAPK14TNFMAPK13MAPK12MAPK11 | |
| SCHEMBL295374 | 0.93 | MAPK14 (0.86) | MAPK14TNFMAPK13MAPK12MAPK11 | |
| SCHEMBL29594426 | 0.93 | MAPK14 (0.86) | MAPK14TNFMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240024490-A1 | BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES | THE BROAD INSTITUTE, INC. | 2024-01-25 | — | — | US | disclosed |
| US-20230192904-A1 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. | 2023-06-22 | — | — | US | disclosed |
| WO-2022225728-A2 | BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES | THE BROAD INSTITUTE, INC. (US) | 2022-10-27 | — | — | WO | disclosed |
| US-11123349-B2 | Method of treatment | THE UNIVERSITY OF MELBOURNE (AU) | 2021-09-21 | — | — | US | disclosed |
| US-20200061074-A1 | METHOD OF TREATMENT | THE UNIVERSITY OF MELBOURNE (AU) | 2020-02-27 | — | — | US | disclosed |
| US-6916924-B2 | Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | disclosed |
| EP-1362037-A1 | PROCESS FOR SYNTHESIS OF HETEROARYL-SUBSTITUTED UREA COMPOUNDS USEFUL AS ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2003-11-19 | — | — | EP | disclosed |
| US-20020123631-A1 | Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-09-05 | — | — | US | disclosed |
| WO-2002066442-A1 | PROCESS FOR SYNTHESIS OF HETEROARYL-SUBSTITUTED UREA COMPOUNDS USEFUL AS ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2002-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11123349-B2 | Method of treatment | TNF, IL1B, IL1A | MAPK14 3859/4885TNF 1/4885MAPK13 3789/4885 |
| US-20240024490-A1 | BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES | COASY, JMJD7, PTMS | MAPK14 2739/4885TNF 4725/4885MAPK13 2417/4885 |
| US-20230192904-A1 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | ERBB2, ACP1, TK1 | MAPK14 594/4885TNF 4704/4885MAPK13 456/4885 |
| US-20200061074-A1 | METHOD OF TREATMENT | TNF, IL1B, IL1A | MAPK14 3859/4885TNF 1/4885MAPK13 3789/4885 |
| US-20020123631-A1 | Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents | URB2, UTS2R, UACA | MAPK14 3928/4885TNF 250/4885MAPK13 4164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.