Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.52 |
| ▸ | FABP4 | P15090 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6330560 | 0.85 | HTR6 (0.58) | HTR6 | |
| SCHEMBL6330390 | 0.81 | HTR6 (0.65) | HTR6 | |
| SCHEMBL6404989 | 0.78 | HTR6 (0.54) | HTR6 | |
| SCHEMBL6332940 | 0.72 | HTR6 (0.51) | HTR6 | |
| SCHEMBL6328502 | 0.71 | HTR6 (0.40) | HTR6 | |
| SCHEMBL3615171 | 0.71 | HTR6 (0.78) | HTR6FABP4KDM4EUBE2NL3MBTL1 | |
| SCHEMBL1172350 | 0.70 | HTR6 (0.77) | HTR6FABP4KDM4EUBE2NL3MBTL1 | |
| SCHEMBL31211647 | 0.70 | HTR6 (0.77) | HTR6FABP4KDM4EUBE2NL3MBTL1 | |
| SCHEMBL6338134 | 0.70 | HTR6 (0.55) | HTR6FABP4KDM4EL3MBTL1 | |
| SCHEMBL14642142 | 0.69 | HTR6 (1.00) | HTR6FABP4KDM4EUBE2NL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849644-B2 | Isoquinoline derivatives useful in the treatment of CNS disorders | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-02-01 | — | — | US | claimed |