Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 11/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | TSHR | P16473 | 9/20 | 0.55 |
| ▸ | HTT | P42858 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6327914 | 0.94 | MAPT (0.56) | LMNAHPGDMAPTTSHRHTT | |
| SCHEMBL6328130 | 0.92 | TSHR (0.68) | LMNAHPGDMAPTTSHRHTT | |
| SCHEMBL6324019 | 0.90 | MAPT (0.59) | LMNAHPGDMAPTTSHRHTT | |
| SCHEMBL6326044 | 0.89 | MAPT (0.56) | LMNAHPGDMAPTTSHRHTT | |
| SCHEMBL6324067 | 0.88 | MAPT (0.72) | LMNAHPGDMAPTTSHRHTT | |
| SCHEMBL6332641 | 0.84 | PARP1 (0.47) | LMNAHPGDMAPTTSHRHTT | |
| SCHEMBL6331273 | 0.82 | MAPT (0.48) | LMNAHPGDMAPTTSHRHTT | |
| SCHEMBL6328650 | 0.76 | PARP1 (0.57) | SMN1; SMN2PARP1 | |
| SCHEMBL6326417 | 0.72 | TSHR (0.60) | LMNAHPGDMAPTTSHRHTT | |
| SCHEMBL6327432 | 0.71 | MAPT (0.54) | LMNAHPGDMAPTTSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924284-B2 | PARP inhibitors | ICOS CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |