Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | TSHR | P16473 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6324019 | 0.93 | MAPT (0.59) | MAPTTSHRHTTALDH1A1LMNA | |
| SCHEMBL6327914 | 0.90 | MAPT (0.56) | MAPTTSHRHTTALDH1A1LMNA | |
| SCHEMBL6324067 | 0.89 | MAPT (0.72) | MAPTTSHRHTTALDH1A1LMNA | |
| SCHEMBL6334598 | 0.89 | LMNA (0.62) | MAPTTSHRHTTALDH1A1LMNA | |
| SCHEMBL6328130 | 0.86 | TSHR (0.68) | MAPTTSHRHTTALDH1A1LMNA | |
| SCHEMBL6331273 | 0.84 | MAPT (0.48) | MAPTTSHRHTTALDH1A1LMNA | |
| SCHEMBL6332641 | 0.80 | PARP1 (0.47) | MAPTTSHRHTTALDH1A1LMNA | |
| SCHEMBL6328504 | 0.77 | HCRTR1 (0.46) | MAPTTSHRHTTALDH1A1LMNA | |
| SCHEMBL6328082 | 0.75 | DNMT3B (0.52) | MAPTTSHRHTTALDH1A1LMNA | |
| SCHEMBL6334127 | 0.74 | CYP1A2 (0.52) | MAPTTSHRHTTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924284-B2 | PARP inhibitors | ICOS CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |