Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.39 |
| ▸ | DRD4 | P21917 | 9/20 | 0.39 |
| ▸ | DRD3 | P35462 | 8/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 8/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6336361 | 0.77 | DRD2 (0.41) | DRD2DRD4DRD3HTR4ACHE | |
| SCHEMBL7259071 | 0.76 | DRD2 (0.40) | DRD2DRD4DRD3HTR4 | |
| SCHEMBL6334766 | 0.76 | DRD4 (0.44) | DRD2DRD4DRD3HTR4 | |
| SCHEMBL6328290 | 0.74 | HRH1 (0.44) | DRD2DRD4DRD3HTR4ACHE | |
| SCHEMBL6329269 | 0.72 | DRD2 (0.58) | DRD2DRD4DRD3HTR4ACHE | |
| SCHEMBL7254055 | 0.72 | HTR4 (0.40) | DRD2DRD4DRD3HTR4 | |
| SCHEMBL7259547 | 0.71 | GRIN1 (0.40) | DRD2DRD4DRD3HTR4 | |
| SCHEMBL6327323 | 0.71 | GRIN1 (0.43) | DRD2DRD4DRD3HTR4 | |
| SCHEMBL6334928 | 0.71 | CACNA1I (0.49) | DRD2DRD4DRD3HTR4 | |
| SCHEMBL6331058 | 0.71 | GSK3B (0.47) | DRD2DRD4DRD3HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6979690-B2 | Oxo or oxy-pyridine compounds as 5-HT4 receptor modulators | PFIZER INC. (US) | 2005-12-27 | — | — | US | disclosed |
| EP-1325921-A2 | Oxo or oxy-pyridine compounds as 5-HT4 receptor modulators | Pfizer Inc. (US) | 2003-07-09 | — | — | EP | disclosed |