Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 4/20 | 0.73 |
| ▸ | EYA3 | Q99504 | 8/20 | 0.72 |
| ▸ | SLC22A12 | Q96S37 | 6/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.72 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | PGR | P06401 | 2/20 | 0.72 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.72 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.72 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.72 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | EYA2 | O00167 | 1/20 | 0.72 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.72 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.72 |
| ▸ | USP2 | O75604 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6336499 | 0.89 | EYA3 (0.73) | TTREYA3SLC22A12CYP2C19NR1H4 | |
| SCHEMBL1287644 | 0.84 | TTR (1.00) | TTREYA3SLC22A12CYP2C19NR1H4 | |
| SCHEMBL6336520 | 0.84 | NR1H4 (0.66) | TTREYA3SLC22A12CYP2C19NR1H4 | |
| Benzbromarone SCHEMBL19205474 | 0.84 | SLC22A12 (1.00) | TTREYA3SLC22A12CYP2C19NR1H4 | |
| Benzbromarone SCHEMBL29361528 | 0.84 | SLC22A12 (1.00) | TTREYA3SLC22A12CYP2C19NR1H4 | |
| Benzbromarone SCHEMBL48993 | 0.84 | SLC22A12 (1.00) | TTREYA3SLC22A12CYP2C19NR1H4 | |
| SCHEMBL25392470 | 0.83 | TTR (0.73) | TTREYA3SLC22A12CYP2C19NR1H4 | |
| SCHEMBL6342546 | 0.82 | EYA3 (0.70) | TTREYA3SLC22A12CYP2C19NR1H4 | |
| Benzbromarone SCHEMBL6761161 | 0.81 | SLC22A12 (0.93) | TTREYA3SLC22A12CYP2C19NR1H4 | |
| SCHEMBL25389841 | 0.78 | EYA3 (0.74) | TTREYA3SLC22A12CYP2C19NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844358-B2 | Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia | WYETH (US) | 2005-01-18 | — | — | US | disclosed |
| US-20040102480-A1 | Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia | WYETH (US) | 2004-05-27 | — | — | US | disclosed |
| US-6509360-B1 | a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia. | WYETH | 2003-01-21 | — | — | US | disclosed |
| EP-1077965-A1 | PHENYL OXO-ACETIC ACIDS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-28 | — | — | EP | disclosed |
| US-6166069-A | Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-12-26 | — | — | US | disclosed |
| WO-1999058519-A1 | PHENYL OXO-ACETIC ACIDS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102480-A1 | Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia | GPR119, INSR, GCKR | TTR 1292/4885EYA3 4109/4885SLC22A12 2400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.