Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKCH | P24723 | 1/20 | 0.39 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 4/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SSTR2 | P30874 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6334984 | 1.00 | NTRK1 (0.43) | NTRK1MAP4K1HTR3AHRH4KMT2A | |
| SCHEMBL6329198 | 1.00 | NTRK1 (0.43) | NTRK1MAP4K1HTR3AHRH4KMT2A | |
| SCHEMBL5802080 | 0.89 | PIM1 (0.41) | NTRK1MAP4K1HTR3AHRH4KMT2A | |
| SCHEMBL6327624 | 0.89 | PIM1 (0.41) | NTRK1MAP4K1HTR3AHRH4KMT2A | |
| SCHEMBL6337199 | 0.87 | L3MBTL1 (0.46) | HTR3AHRH4PIM1PIM2SSTR2 | |
| SCHEMBL6330939 | 0.87 | L3MBTL1 (0.46) | HTR3AHRH4PIM1PIM2SSTR2 | |
| SCHEMBL6337475 | 0.87 | L3MBTL1 (0.46) | HTR3AHRH4PIM1PIM2SSTR2 | |
| SCHEMBL5787010 | 0.80 | ALDH1A1 (0.52) | NTRK1KMT2APRKCBPRKCAPRKCH | |
| SCHEMBL5788983 | 0.80 | PRKCB (0.55) | HTR3AHRH4KMT2APRKCBPRKCA | |
| SCHEMBL6331657 | 0.76 | ADORA2A (0.52) | HTR3APIM1PIM3PIM2SSTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050096327-A1 | Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders | WARNER-LAMBERT COMPANY LLC | 2005-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096327-A1 | Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders | SLC6A2, SLC18A2, SLC6A3 | NTRK1 332/4885MAP4K1 1338/4885HTR3A 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.