Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 9/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.34 |
| ▸ | RXRA | P19793 | 7/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6335039 | 0.85 | NR1H2 (0.39) | JAK2JAK1NR1H2NR1H3RXRA | |
| SCHEMBL6332911 | 0.81 | NR1H2 (0.39) | JAK2JAK1NR1H2NR1H3RXRA | |
| SCHEMBL16423025 | 0.73 | LMNA (0.42) | JAK2JAK1SETD7 | |
| SCHEMBL5761284 | 0.73 | CHRNA7 (0.37) | JAK2JAK1NR1H2NR1H3RXRA | |
| SCHEMBL5757976 | 0.72 | ALDH1A1 (0.37) | JAK2JAK1NR1H2NR1H3RXRA | |
| SCHEMBL6330650 | 0.72 | NR1H2 (0.33) | NR1H2NR1H3RXRAGPR119ABCB1 | |
| SCHEMBL18689673 | 0.71 | JAK2 (0.44) | JAK2JAK1NR1H2NR1H3RXRA | |
| SCHEMBL18616707 | 0.70 | GRM5 (0.44) | JAK2JAK1NR1H2NR1H3RXRA | |
| SCHEMBL30867740 | 0.70 | POLB (0.40) | JAK2JAK1NR1H2NR1H3RXRA | |
| SCHEMBL30868167 | 0.70 | POLB (0.40) | JAK2JAK1NR1H2NR1H3RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6881733-B1 | Serotonergic benzofurans | ELI LILLY AND COMPANY (US) | 2005-04-19 | — | — | US | disclosed |
| EP-1204659-B1 | SEROTONERGIC BENZOFURANS | LILLY CO ELI (US) | 2003-11-26 | — | — | EP | disclosed |
| EP-1204659-A2 | SEROTONERGIC BENZOFURANS | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009122-A2 | SEROTONERGIC BENZOFURANS | ELI LILLY AND COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |