Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.30 |
| ▸ | GRM5 | P41594 | 2/20 | 0.30 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | TNF | P01375 | 1/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
| ▸ | RXRA | P19793 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6334848 | 0.84 | GYS1 (0.34) | NR1H2NR1H3GPR119GHSRUSP30 | |
| SCHEMBL6339270 | 0.83 | GYS1 (0.37) | NR1H2NR1H3GPR119 | |
| SCHEMBL6340611 | 0.78 | LMNA (0.33) | NR1H2NR1H3GPR119GHSRUSP30 | |
| Hydrochloric Acid SCHEMBL7474626 | 0.77 | CDK9 (0.32) | — | |
| SCHEMBL6335122 | 0.73 | TSHR (0.34) | GHSRUSP30GRM5 | |
| SCHEMBL6338071 | 0.72 | JAK2 (0.35) | NR1H2NR1H3GPR119ABCB1USP30 | |
| SCHEMBL6330870 | 0.68 | GYS1 (0.36) | NR1H2NR1H3USP30GRM5GRM1 | |
| SCHEMBL6310341 | 0.67 | MAPT (0.42) | GRM5GRM1 | |
| Hydrochloric Acid SCHEMBL6333493 | 0.67 | CCNT1 (0.33) | — | |
| SCHEMBL16271998 | 0.67 | GPR119 (0.47) | GPR119GRM5GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6881733-B1 | Serotonergic benzofurans | ELI LILLY AND COMPANY (US) | 2005-04-19 | — | — | US | disclosed |
| EP-1204659-B1 | SEROTONERGIC BENZOFURANS | LILLY CO ELI (US) | 2003-11-26 | — | — | EP | disclosed |