Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14405820 | 0.73 | GAA (0.59) | LMNAMAPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23447516 | 0.73 | SMN1; SMN2 (0.68) | MAPK1NPC1RAB9ASMN1; SMN2MAPT | |
| Water SCHEMBL2340363 | 0.72 | MRGPRX4 (0.50) | LMNAMAPK1MAPTMRGPRX4ALDH1A1 | |
| SCHEMBL3020985 | 0.71 | MAPK1 (0.53) | LMNAMAPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22703497 | 0.71 | L3MBTL1 (0.57) | LMNAMAPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5908191 | 0.70 | GAA (0.59) | LMNAMAPK1MAPTGAAALDH1A1 | |
| Glycine SCHEMBL8986630 | 0.70 | MRGPRX4 (0.48) | MAPK1MAPTMRGPRX4ALDH1A1L3MBTL1 | |
| SCHEMBL9713841 | 0.70 | NPSR1 (0.56) | LMNAMAPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8015222 | 0.70 | L3MBTL1 (0.57) | LMNAMAPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3928072 | 0.70 | CYP19A1 (0.55) | RAB9ASMN1; SMN2MAPTGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2419433-A1 | HEPATITIS C VIRUS INHIBITORS | Bristol-Myers Squibb Company (US) | 2012-02-22 | — | — | EP | disclosed |
| WO-2010120621-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-10-21 | — | — | WO | disclosed |