SCHEMBL634023

SCHEMBL634023

CCN(CC)CCC(=O)c1cccc(Cl)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.54
HPGD P15428 2/20 0.54
ERCC5 P28715 1/20 0.50
FEN1 P39748 1/20 0.50
PARP1 P09874 1/20 0.46
KCNH2 Q12809 2/20 0.45
DRD2 P14416 1/20 0.45
DRD3 P35462 1/20 0.45
MAPT P10636 2/20 0.44
GAA P10253 1/20 0.44
HTT P42858 1/20 0.44
KMT2A Q03164 2/20 0.44
LMNA P02545 1/20 0.43
TSHR P16473 1/20 0.43
HSD11B1 P28845 1/20 0.42
PKM P14618 1/20 0.42
CHRNA1 P02708 1/20 0.42
CHRNG P07510 1/20 0.42
ITGA5 P08648 1/20 0.42
CHRNB1 P11230 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5954219 0.84 THRA (0.53) ALDH1A1HPGDERCC5FEN1PARP1
Hydrochloric Acid SCHEMBL5858790 0.83 THRA (0.52) ALDH1A1HPGDERCC5FEN1PARP1
SCHEMBL634434 0.82 ERCC5 (0.57) ALDH1A1HPGDERCC5FEN1PARP1
SCHEMBL5954123 0.81 CTNNB1 (0.49) HPGDPARP1KCNH2MAPTHTT
SCHEMBL5953952 0.80 GSK3B (0.53) ALDH1A1ERCC5FEN1MAPTKMT2A
SCHEMBL6322827 0.80 KMT2A (0.67) ALDH1A1HPGDMAPTGAAHTT
SCHEMBL633895 0.79 ALDH1A1 (0.57) ALDH1A1HPGDERCC5FEN1PARP1
Hydrochloric Acid SCHEMBL10670271 0.78 KMT2A (0.65) ALDH1A1HPGDMAPTGAAKMT2A
SCHEMBL4394372 0.78 ERCC5 (0.57) ALDH1A1ERCC5FEN1PARP1KMT2A
SCHEMBL116338 0.78 ERCC5 (0.61) ALDH1A1HPGDERCC5FEN1PARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2419400-A1 MONOAMINE REUPTAKE INHIBITORS RESEARCH TRIANGLE INSTITUTE (US) 2012-02-22 EP disclosed