SCHEMBL6340796

SCHEMBL6340796

Cc1cccc([SiH2]CO)c1C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.43
ATM Q13315 1/20 0.43
ALDH1A1 P00352 4/20 0.37
KMT2A Q03164 2/20 0.35
CYP1A2 P05177 1/20 0.33
CYP2A6 P11509 1/20 0.33
ESR1 P03372 1/20 0.33
ESR2 Q92731 1/20 0.33
MAPT P10636 4/20 0.33
TP53 P04637 1/20 0.33
GAA P10253 1/20 0.33
MAPK1 P28482 1/20 0.33
HSD17B10 Q99714 1/20 0.33
TSHR P16473 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA7 P43166 1/20 0.32
CA9 Q16790 1/20 0.32
ACHE P22303 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23701069 0.84 ACHE (0.43) TRPA1ATMALDH1A1CYP1A2MAPT
SCHEMBL1470830 0.83 TRPA1 (0.40) TRPA1ATMALDH1A1KMT2ACYP1A2
SCHEMBL9217674 0.82 TRPA1 (0.41) TRPA1ATMALDH1A1CYP1A2CYP2A6
SCHEMBL10523368 0.78 TRPA1 (0.38) TRPA1ATMALDH1A1CYP1A2CYP2A6
SCHEMBL7033569 0.78 TRPA1 (0.38) TRPA1ATMALDH1A1CYP1A2CYP2A6
SCHEMBL852173 0.78 TRPA1 (0.38) TRPA1ATMALDH1A1CYP1A2CYP2A6
SCHEMBL9343766 0.78 TRPA1 (0.38) TRPA1ATMALDH1A1CYP1A2CYP2A6
SCHEMBL8388510 0.77 TRPA1 (0.39) TRPA1ATMALDH1A1
SCHEMBL11206939 0.75 TRPA1 (0.36) TRPA1ATMALDH1A1KMT2ACYP1A2
SCHEMBL2175294 0.75 TRPA1 (0.48) TRPA1ATMALDH1A1KMT2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-61263988-A None JP disclosed
US-6913629-B2 Building blocks containing isocyanate groups and their use for functionalizing or modifying compounds or surfaces BASF AKTIENGESELLSCHAFT (DE) 2005-07-05 US disclosed
US-20010005738-A1 Building blocks containing isocyanate groups and their use for functionalizing or modifying compounds or surfaces BASF AKTIENGESELLSCHAFT (DE) 2001-06-28 US disclosed
EP-1110946-A2 Subunits containing isocyanate groups and their use for functionalising or modifying compounds or surfaces BASF AKTIENGESELLSCHAFT (DE) 2001-06-27 EP disclosed
US-6232261-B1 REACTION PRODUCT OF AN ALUMINOXANE OR PRODUCT OF AN ALKYLALUMINUM AND WATER WITH A SILICON-CONTAINING COMPOUND, FOR EXAMPLE DIPHENYLSILANE DIOL; OLEFIN POLYMERIZATION CATALYST, ESPECIALLY A METALLOCENE COMPLEX BP CHEMICALS LIMITED (GB) 2001-05-15 US disclosed
EP-0952991-A1 CATALYST ACTIVATORS BP Chemicals Limited (GB) 1999-11-03 EP disclosed
WO-1998031715-A1 CATALYST ACTIVATORS BP CHEMICALS LIMITED (GB) 1998-07-23 WO disclosed
EP-0202893-B1 PESTICIDAL SILYLMETHYL ETHER COMPOUNDS SHIONOGI & CO., LTD. (JP) 1990-01-03 EP disclosed
US-4663314-A PESTICIDES SHIONOGI & CO., LTD. (JP) 1987-05-05 US disclosed
EP-0202893-A2 Pesticidal silylmethyl ether compounds SHIONOGI & CO., LTD. (JP) 1986-11-26 EP disclosed
JP-S61263988-A SILYL-SUBSTITUTED ETHER AND INSECTICIDAL AND MITICIDAL AGENT CONTAINING SAME SHIONOGI & CO LTD 1986-11-21 JP disclosed