Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6338629 | 0.77 | HSD11B1 (0.59) | EPHX2HSD11B1CYP2C9ALDH1A1L3MBTL1 | |
| SCHEMBL6336061 | 0.75 | HSD11B1 (0.52) | EPHX2HSD11B1NPC1L3MBTL1EPHX1 | |
| SCHEMBL6339317 | 0.75 | EPHX2 (0.46) | EPHX2HSD11B1ALDH1A1MAPTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL6339152 | 0.74 | HSD11B1 (0.45) | EPHX2HSD11B1ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL20399124 | 0.73 | USP2 (0.47) | EPHX2HTTNPC1ALDH1A1MAPT | |
| SCHEMBL1514910 | 0.73 | USP2 (0.47) | EPHX2HTTNPC1ALDH1A1MAPT | |
| SCHEMBL72304 | 0.73 | EPHX1 (0.53) | EPHX2HSD11B1CYP2C9HTTNPC1 | |
| SCHEMBL24669979 | 0.72 | USP2 (0.50) | EPHX2HTTNPC1ALDH1A1MAPT | |
| SCHEMBL64202 | 0.72 | USP2 (0.50) | EPHX2HTTNPC1ALDH1A1MAPT | |
| SCHEMBL27365962 | 0.72 | USP2 (0.50) | EPHX2HTTNPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261302-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application | ABBOTT LABORATORIES | 2005-11-24 | — | — | US | disclosed |
| US-20050245533-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenaseType 1 enzyme and their therapeutic application | ABBOTT LABORATORIES | 2005-11-03 | — | — | US | disclosed |
| US-20050245532-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application | ABBOTT LABORATORIES | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245532-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application | HSD11B1, HSD17B1, HSD3B1 | EPHX2 696/4885HSD11B1 1/4885CYP2C9 720/4885 |
| US-20050245533-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenaseType 1 enzyme and their therapeutic application | HSD11B1, HSD17B1, HSD3B1 | EPHX2 676/4885HSD11B1 1/4885CYP2C9 456/4885 |
| US-20050261302-A1 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application | HSD11B1, HSD17B1, HSD3B1 | EPHX2 696/4885HSD11B1 1/4885CYP2C9 720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.