Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8103317 | 0.91 | TSHR (0.41) | PHGDHHPGDTSHRSMN1; SMN2GAA | |
| SCHEMBL8103321 | 0.91 | TSHR (0.41) | PHGDHHPGDTSHRSMN1; SMN2GAA | |
| SCHEMBL6344139 | 0.90 | HPGD (0.36) | HPGDTSHRKMT2AMEN1SMN1; SMN2 | |
| Iodide SCHEMBL5949583 | 0.89 | SMN1; SMN2 (0.41) | PHGDHHPGDTSHRSMN1; SMN2GAA | |
| Iodide SCHEMBL5949586 | 0.89 | SMN1; SMN2 (0.41) | PHGDHHPGDTSHRSMN1; SMN2GAA | |
| SCHEMBL8103467 | 0.79 | ACHE (0.42) | HPGDTSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8103469 | 0.79 | ACHE (0.42) | HPGDTSHRKMT2AMEN1SMN1; SMN2 | |
| Iodide SCHEMBL5948720 | 0.78 | KDM4E (0.44) | HPGDTSHRKMT2AMEN1SMN1; SMN2 | |
| Iodide SCHEMBL5948723 | 0.78 | KDM4E (0.44) | HPGDTSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8103388 | 0.71 | MAPT (0.38) | PHGDHHPGDTSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004168-A1 | New substituted pyridine or piperidine compounds | METH-COHN OTTO (GB) | 2005-01-06 | — | — | US | disclosed |
| US-20020040036-A1 | New substituted pyridine or piperidine compounds | ADIR ET COMPAGNIE | 2002-04-04 | — | — | US | disclosed |
| US-20020035123-A1 | New substituted pyridine or piperidine compounds | ADIR ET COMPAGNIE | 2002-03-21 | — | — | US | disclosed |
| US-6323220-B1 | COGNITION ACTIVATORS AND TREATMENT OF NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 2001-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004168-A1 | New substituted pyridine or piperidine compounds | HRH3, HRH4, HRH1 | PHGDH 1746/4885HPGD 173/4885TSHR 1953/4885 |
| US-20020035123-A1 | New substituted pyridine or piperidine compounds | OPRD1, CNR1, HRH4 | PHGDH 1548/4885HPGD 359/4885TSHR 3127/4885 |
| US-20020040036-A1 | New substituted pyridine or piperidine compounds | CNR1, OPRD1, OPRK1 | PHGDH 1393/4885HPGD 403/4885TSHR 3127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.