Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.51 |
| ▸ | CTSS | P25774 | 3/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.42 |
| ▸ | AKT1 | P31749 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3425339 | 0.86 | ATM (0.51) | CTSKCTSSIDO1CA12CA1 | |
| Water SCHEMBL27509393 | 0.85 | CTSS (0.51) | CTSKCTSSIDO1CA12CA1 | |
| SCHEMBL487448 | 0.84 | CTSK (0.49) | CTSKCTSS | |
| SCHEMBL487446 | 0.84 | CTSK (0.49) | CTSKCTSS | |
| SCHEMBL28205495 | 0.80 | ATM (0.52) | CTSKCTSSIDO1CA12CA1 | |
| SCHEMBL29077117 | 0.78 | ATM (0.51) | CTSKCTSSIDO1CA12CA1 | |
| SCHEMBL22042132 | 0.78 | CTSK (0.62) | CTSKCTSSCA12CA1CA7 | |
| SCHEMBL28108976 | 0.78 | CTSK (0.62) | CTSKCTSSCA12CA1CA7 | |
| SCHEMBL3786555 | 0.78 | TDP1 (0.50) | CTSKCTSSIDO1CA12CA1 | |
| SCHEMBL27730329 | 0.78 | CTSK (0.62) | CTSKCTSSCA12CA1CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960575-B2 | For use as inhibitors of chymase | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2005-11-01 | — | — | US | disclosed |
| US-6713472-B1 | 2-OXO-1,2,3,4-TETRAHYDROPYRAZINE DERIVATIVES; CHYMASE INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-03-30 | — | — | US | disclosed |