Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MAOA | P21397 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13323 | 0.80 | ALDH1A1 (0.60) | ALDH1A1MEN1GAAKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL30648399 | 0.78 | ALDH1A1 (0.58) | ALDH1A1MEN1GAAKMT2AMAPT | |
| SCHEMBL4811332 | 0.72 | ALDH1A1 (0.60) | ALDH1A1L3MBTL1MEN1GAAKMT2A | |
| SCHEMBL19497757 | 0.72 | ALDH1A1 (0.60) | ALDH1A1L3MBTL1MEN1GAAKMT2A | |
| SCHEMBL88687 | 0.72 | ALDH1A1 (1.00) | ALDH1A1L3MBTL1MEN1GAAKMT2A | |
| SCHEMBL12463182 | 0.69 | L3MBTL1 (0.66) | ALDH1A1L3MBTL1MEN1GAAKMT2A | |
| SCHEMBL12462878 | 0.69 | L3MBTL1 (0.66) | ALDH1A1L3MBTL1MEN1GAAKMT2A | |
| SCHEMBL10337207 | 0.69 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1MEN1GAAKMT2A | |
| SCHEMBL7427944 | 0.69 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1MEN1GAAKMT2A | |
| SCHEMBL1756087 | 0.69 | HDAC1 (0.51) | ALDH1A1L3MBTL1MEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6875877-B2 | Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides | LI JINGLIN JAMES T (US) | 2005-04-05 | — | — | US | disclosed |
| EP-1331225-A1 | Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides | G.D. SEARLE & CO. (US) | 2003-07-30 | — | — | EP | disclosed |
| EP-1042314-B1 | METHOD OF PREPARING ENANTIOMERICALLY-ENRICHED TETRAHYDROBENZOTHIEPINE OXIDES | SEARLE & CO (US) | 2003-03-19 | — | — | EP | disclosed |
| US-20020188119-A1 | Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides | LI JINGLIN (US) | 2002-12-12 | — | — | US | disclosed |
| US-6369220-B1 | OXIDIZING AN ARYL-3-HYDROXYPROPYLSULFIDE; OXIDIZING 3-HYDROXY GROUP INTO ARYL-3-PROPANALSULFOXIDE; CYCLIZATION | G.D. SEARLE, LLC | 2002-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020188119-A1 | Method of preparing enantiomerically-enriched tetrahydrobenzothiepine oxides | TST, THOP1, TH | ALDH1A1 767/4885L3MBTL1 3566/4885MEN1 3795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.