Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.32 |
| ▸ | MMP13 | P45452 | 5/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.31 |
| ▸ | MMP2 | P08253 | 4/20 | 0.31 |
| ▸ | MMP14 | P50281 | 3/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6355074 | 0.97 | GRIA4 (0.36) | GRIA4KCNH2ADAM17MMP13SLC22A12 | |
| SCHEMBL6410380 | 0.93 | GRIA4 (0.34) | GRIA4KCNH2ADAM17MMP13MMP2 | |
| SCHEMBL6348910 | 0.85 | GRIA4 (0.36) | GRIA4KCNH2ADAM17MMP13GRIA2 | |
| SCHEMBL6346464 | 0.84 | ADAM17 (0.33) | ADAM17MMP13MMP2MMP1CYP3A4 | |
| SCHEMBL6345330 | 0.84 | MEN1 (0.37) | GRIA4ADAM17ALDH1A1MEN1KMT2A | |
| SCHEMBL6348951 | 0.83 | HRH3 (0.35) | KCNH2CYP2D6ALDH1A1MEN1KMT2A | |
| SCHEMBL6239464 | 0.82 | RORC (0.42) | ADAM17MMP13MMP2MMP9RAB9A | |
| SCHEMBL6345959 | 0.82 | RORC (0.42) | ADAM17MMP13MMP2MMP9RAB9A | |
| SCHEMBL6345321 | 0.82 | RORC (0.42) | ADAM17MMP13MMP2MMP9RAB9A | |
| SCHEMBL6345477 | 0.82 | ALDH1A1 (0.41) | ALDH1A1MEN1RAB9AKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900353-B2 | Cyclopentyl sulfonamide derivatives | ELI LILLY AND COMPANY (US) | 2005-05-31 | — | — | US | disclosed |
| US-20040067984-A1 | Cyclopentyl sulfonamide derivatives | CANTRELL BUDDY EUGENE (US) | 2004-04-08 | — | — | US | disclosed |
| EP-1334087-A1 | CYCLOALKYLFLUOROSULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002032858-A1 | CYCLOALKYLFLUOROSULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067984-A1 | Cyclopentyl sulfonamide derivatives | GRIN2A, GRIN1, GRIK5 | GRIA4 15/4885KCNH2 618/4885ADAM17 3636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.