Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | BTK | Q06187 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23909581 | 0.82 | KMT2A (0.47) | KMT2AATMKDM4EALDH1A1GAA | |
| SCHEMBL6135290 | 0.82 | ATM (0.61) | KMT2AATMKDM4EALDH1A1GAA | |
| SCHEMBL634722 | 0.80 | ATM (0.55) | KMT2AATMKDM4EALDH1A1GAA | |
| SCHEMBL11607263 | 0.79 | CYP1A2 (0.54) | KMT2AATMKDM4EALDH1A1GAA | |
| SCHEMBL30471810 | 0.78 | BCAT2 (0.52) | KDM4EALDH1A1GAAPARP1BTK | |
| SCHEMBL39964 | 0.75 | KDM4E (0.52) | KDM4EALDH1A1GAAPARP1BCAT2 | |
| SCHEMBL7916759 | 0.74 | NR4A1 (0.59) | KMT2AATMKDM4EALDH1A1GAA | |
| SCHEMBL353488 | 0.74 | BCAT2 (0.53) | KMT2AATMKDM4EALDH1A1GAA | |
| SCHEMBL23909595 | 0.74 | KMT2A (0.42) | KMT2AATMKDM4EALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL4562961 | 0.73 | PARP1 (0.50) | KDM4EALDH1A1GAAPARP1BCAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2418942-A1 | NAPHTHALENE-BASED INHIBITORS OF ANTI-APOPTOTIC PROTEINS | Sanford-Burnham Medical Research Institute (US) | 2012-02-22 | — | — | EP | disclosed |