SCHEMBL6348188

SCHEMBL6348188

Oc1cc2cc(Cl)ccc2c(O)c1O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 4/20 0.43
ALDH1A1 P00352 3/20 0.43
CYP3A4 P08684 3/20 0.43
TSHR P16473 2/20 0.43
DAO P14920 2/20 0.43
TDP1 Q9NUW8 1/20 0.43
HPGD P15428 4/20 0.40
ALOX15 P16050 3/20 0.40
ALOX12 P18054 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
MAPK1 P28482 1/20 0.40
HIF1A Q16665 3/20 0.39
HSP90AA1 P07900 3/20 0.39
MEN1 O00255 2/20 0.39
HTT P42858 2/20 0.39
KMT2A Q03164 2/20 0.39
CYP2C9 P11712 2/20 0.39
CYP2C19 P33261 2/20 0.39
LMNA P02545 2/20 0.39
MAPT P10636 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6356363 0.78 PTPN22 (0.50) HSD17B10ALDH1A1CYP3A4TSHRTDP1
SCHEMBL16632509 0.77 HSD17B10 (0.52) HSD17B10ALDH1A1CYP3A4TSHRDAO
SCHEMBL9616211 0.75 CYP2A6 (0.50) HSD17B10ALDH1A1HPGDMEN1KMT2A
SCHEMBL15600490 0.75 TRPM4 (0.63) HSD17B10ALDH1A1CYP3A4TSHRDAO
SCHEMBL6346791 0.74 CA3 (0.48) HSD17B10ALDH1A1CYP3A4DAOTDP1
SCHEMBL22275435 0.74 NQO2 (0.54) HSD17B10ALDH1A1CYP3A4TSHRDAO
SCHEMBL3862631 0.74 TSHR (0.48) HSD17B10ALDH1A1CYP3A4TSHRDAO
SCHEMBL6355043 0.74 TRPA1 (0.44) HSD17B10ALDH1A1DAOTDP1HPGD
SCHEMBL6345737 0.74 ERN1 (0.46) ALDH1A1HPGDALOX15MEN1KMT2A
SCHEMBL30079854 0.74 NQO2 (0.54) HSD17B10ALDH1A1CYP3A4TSHRDAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6878659-B2 Solid catalyst component for olefin polymerization and catalyst TOHO TITANIUM CO., LTD. (JP) 2005-04-12 US disclosed
US-20040072681-A1 Solid catalyst component for olefin polymerization and catalyst TOHO TITANIUM CO., LTD. (JP) 2004-04-15 US disclosed
EP-1260524-A1 SOLID CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST Toho Titanium Co., Ltd. (JP) 2002-11-27 EP disclosed