Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FADS1 | O60427 | 1/20 | 0.49 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CBS | P35520 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1686631 | 0.87 | FADS1 (0.59) | FADS1KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL12614443 | 0.84 | RAPGEF4 (0.59) | RAPGEF4KMT2AMEN1MAPTLMNA | |
| SCHEMBL331059 | 0.83 | ALDH1A1 (0.59) | RAPGEF4KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL6076594 | 0.80 | EPHX1 (0.57) | RAPGEF4KMT2AMEN1MAPTLMNA | |
| SCHEMBL30342506 | 0.80 | MEN1 (0.68) | FADS1KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL3951892 | 0.80 | MEN1 (0.68) | FADS1KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL457521 | 0.80 | MEN1 (0.79) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL16566494 | 0.80 | ALDH1A1 (0.71) | KMT2AMEN1MAPTALDH1A1GAA | |
| SCHEMBL22824462 | 0.78 | MAPT (0.53) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL7913356 | 0.78 | HPGD (0.59) | FADS1KMT2AMEN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936607-B2 | 2,4,6-Triaminopyrimidines for the treatment of depression and/or anxiety | H. LUNOBECK A/S (DK) | 2005-08-30 | — | — | US | disclosed |