Sugi Predict

Sugi Predict / Compounds / SCHEMBL6353477

SCHEMBL6353477

SCHEMBL6353477

CCOC(=O)C1CC1C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 8/20 0.39
▸ CA2 P00918 8/20 0.39
▸ CA9 Q16790 6/20 0.39
▸ CA12 O43570 6/20 0.39
▸ MAPT P10636 2/20 0.37
▸ KDM4E B2RXH2 2/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ HPGD P15428 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ CYP1A2 P05177 1/20 0.36
▸ TSHR P16473 1/20 0.36
▸ CYP2C19 P33261 1/20 0.36
▸ PKM P14618 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26244796 1.00 CA1 (0.39) CA1CA2CA9CA12MAPT
SCHEMBL25434524 1.00 CA1 (0.39) CA1CA2CA9CA12MAPT
SCHEMBL21442116 0.85 PPM1B (0.38) ALDH1A1TSHR
SCHEMBL420137 0.82 CA1 (0.40) CA1CA2CA9CA12MAPT
SCHEMBL9264305 0.82 CA1 (0.40) CA1CA2CA9CA12MAPT
SCHEMBL16730143 0.81 L3MBTL1 (0.40) CA1CA2CA9CA12KDM4E
SCHEMBL25374417 0.81 CA1 (0.39) CA1CA2CA9CA12MAPT
SCHEMBL8914013 0.79 ALDH1A1 (0.48) CA1CA2CA9CA12MAPT
SCHEMBL2705851 0.79 ALDH1A1 (0.48) CA1CA2CA9CA12MAPT
SCHEMBL2705849 0.79 ALDH1A1 (0.48) CA1CA2CA9CA12MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230399314-A1 CD73 INHIBITOR AND USE THEREOF Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) 2023-12-14 — — US disclosed
US-20230399314-A1 CD73 INHIBITOR AND USE THEREOF Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) 2023-12-14 — — US disclosed
US-20230399314-A1 CD73 INHIBITOR AND USE THEREOF Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) 2023-12-14 — — US disclosed
EP-4242204-A1 CD73 INHIBITOR AND USE THEREOF Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) 2023-09-13 — — EP disclosed
EP-4242204-A1 CD73 INHIBITOR AND USE THEREOF Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) 2023-09-13 — — EP disclosed
WO-2022095975-A1 CD73 INHIBITOR AND USE THEREOF 武汉人福创新药物研发中心有限公司 2022-05-12 — — WO disclosed
WO-2022095975-A1 CD73 INHIBITOR AND USE THEREOF 武汉人福创新药物研发中心有限公司 2022-05-12 — — WO disclosed
CN-114437039-A CD73 inhibitor and application thereof 武汉人福创新药物研发中心有限公司 2022-05-06 — — CN disclosed
CN-107922392-B 1- (hetero) arylsulfonyl- (pyrrolidine or piperidine) -2-carboxamide derivatives and uses thereof 豪夫迈·罗氏有限公司 2020-07-21 — — CN disclosed
EP-3256463-B1 1-(HET)ARYLSULFONYL-(PYRROLIDINE OR PIPERIDINE)-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS HOFFMANN LA ROCHE (CH) 2019-10-09 — — EP disclosed
US-10179782-B2 Substituted sulfonamide compounds GENENTECH, INC. (US) 2019-01-15 — — US disclosed
CN-107922392-A 1 (miscellaneous) aryl sulfonyl (pyrrolidines or piperidines) 2 carboxamides derivatives and its purposes as TRPA1 antagonists 豪夫迈·罗氏有限公司 2018-04-17 — — CN disclosed
EP-3256463-A1 1-(HET)ARYLSULFONYL-(PYRROLIDINE OR PIPERIDINE)-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS F. Hoffmann-La Roche AG (CH) 2017-12-20 — — EP disclosed
US-20160264567-A1 SUBSTITUTED SULFONAMIDE COMPOUNDS GENENTECH, INC. (US) 2016-09-15 — — US disclosed
US-20160264567-A1 SUBSTITUTED SULFONAMIDE COMPOUNDS GENENTECH, INC. (US) 2016-09-15 — — US disclosed
US-20160264567-A1 SUBSTITUTED SULFONAMIDE COMPOUNDS GENENTECH, INC. (US) 2016-09-15 — — US disclosed
WO-2016128529-A1 1-(HET)ARYLSULFONYL-(PYRROLIDINE OR PIPERIDINE)-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2016-08-18 — — WO disclosed
WO-2016128529-A1 1-(HET)ARYLSULFONYL-(PYRROLIDINE OR PIPERIDINE)-2-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2016-08-18 — — WO disclosed
US-20050096354-A1 Process for the preparation of substituted aryl pyrazoles PFIZER, INC. (US) 2005-05-05 — — US disclosed
WO-2005023773-A1 PROCESS FOR THE PREPARATION OF SUBSTITUTED ARYL PYRAZOLES PFIZER LIMITED (GB) 2005-03-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10179782-B2 Substituted sulfonamide compounds TRPA1, TRPV1, TRPV5 CA1 1000/4885CA2 139/4885CA9 249/4885
US-20230399314-A1 CD73 INHIBITOR AND USE THEREOF ENTPD5, ENTPD1, NT5E CA1 573/4885CA2 539/4885CA9 409/4885
US-20050096354-A1 Process for the preparation of substituted aryl pyrazoles CYP3A5, DDT, CYP3A4 CA1 3462/4885CA2 2290/4885CA9 3918/4885
US-20160264567-A1 SUBSTITUTED SULFONAMIDE COMPOUNDS TRPA1, TRPV1, TRPV5 CA1 1000/4885CA2 139/4885CA9 249/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.