Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12319067 | 0.78 | HDAC1 (0.53) | HDAC6HDAC1HDAC4HDAC3ALDH1A1 | |
| SCHEMBL2409095 | 0.74 | DAO (0.60) | ALDH1A1KDM4EPOLBMAPTCYP2C9 | |
| SCHEMBL12272028 | 0.74 | DAO (0.60) | ALDH1A1KDM4EPOLBMAPTCYP2C9 | |
| SCHEMBL1587163 | 0.73 | ALDH1A1 (0.51) | HDAC6HDAC1HDAC4HDAC3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2406962 | 0.73 | DAO (0.58) | ALDH1A1KDM4EPOLBMAPTCYP2C9 | |
| Hydrochloric Acid SCHEMBL2406963 | 0.73 | DAO (0.58) | ALDH1A1KDM4EPOLBMAPTCYP2C9 | |
| SCHEMBL14448557 | 0.70 | NPSR1 (0.50) | ALDH1A1KDM4EPOLBMAPTCYP2C9 | |
| SCHEMBL2406988 | 0.70 | NPSR1 (0.50) | ALDH1A1KDM4EPOLBMAPTCYP2C9 | |
| SCHEMBL276955 | 0.70 | ALDH1A1 (0.58) | HDAC6HDAC1HDAC4HDAC3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2408434 | 0.69 | NPSR1 (0.49) | ALDH1A1KDM4EPOLBMAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050154048-A1 | Novel acyl hydrazino thiophene derivatives, process for preparing them, their use as medicinal products, pharmaceutical compositions and novel use | AVENTIS PHARMA S.A. (FR) | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050154048-A1 | Novel acyl hydrazino thiophene derivatives, process for preparing them, their use as medicinal products, pharmaceutical compositions and novel use | CTSZ, CTSE, CTSS | HDAC6 40/4885HDAC1 109/4885HDAC4 180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.