Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 16/20 | 0.62 |
| ▸ | DRD2 | P14416 | 4/20 | 0.62 |
| ▸ | DRD3 | P35462 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343202 | 0.90 | HTR1A (0.52) | HTR1ADRD2DRD3 | |
| SCHEMBL7342236 | 0.86 | HTR1A (0.62) | HTR1ADRD2DRD3 | |
| SCHEMBL6354089 | 0.83 | HTR1A (0.56) | HTR1ADRD2DRD3 | |
| SCHEMBL7343418 | 0.77 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| SCHEMBL6361234 | 0.76 | DRD2 (0.61) | HTR1ADRD2DRD3 | |
| SCHEMBL7341546 | 0.76 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| SCHEMBL7349651 | 0.76 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| SCHEMBL7343414 | 0.75 | HTR1A (0.40) | HTR1ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL7349931 | 0.75 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| SCHEMBL7344215 | 0.74 | HTR1A (0.79) | HTR1ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050250803-A1 | Combination of dopamine agonists and monoamine reuptake inhibitors | PFIZER INC | 2005-11-10 | — | — | US | claimed |
| WO-2005051488-A1 | COMBINATION OF DOPAMINE AGONISTS AND MONOAMINE REUPTAKE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2005-06-09 | — | — | WO | claimed |
| EP-0480939-B1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | UPJOHN CO (US) | 1995-01-25 | — | — | EP | claimed |
| US-5273975-A | Heterocyclic amines having central nervous system activity | THE UPJOHN COMPANY (US) | 1993-12-28 | — | — | US | claimed |
| WO-1990015058-A1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1990-12-13 | — | — | WO | claimed |
| US-20050250803-A1 | Combination of dopamine agonists and monoamine reuptake inhibitors | PFIZER INC | 2005-11-10 | — | — | US | disclosed |
| WO-2005051488-A1 | COMBINATION OF DOPAMINE AGONISTS AND MONOAMINE REUPTAKE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2005-06-09 | — | — | WO | disclosed |
| US-5436240-A | Schizophrenia, Parkinson's disease, depression or hypotensive agents using tricyclic amines | THE UPJOHN COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0480939-B1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | UPJOHN CO (US) | 1995-01-25 | — | — | EP | disclosed |
| US-5273975-A | Heterocyclic amines having central nervous system activity | THE UPJOHN COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| WO-1990015058-A1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1990-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250803-A1 | Combination of dopamine agonists and monoamine reuptake inhibitors | HTR5A, SLC6A3, SLC6A4 | HTR1A 5/4885DRD2 37/4885DRD3 118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.