SCHEMBL6354479

SCHEMBL6354479

COc1c(C(=O)OC(C)=O)ccc(CBr)c1C(=O)OC(C)=O

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.31
▸ LMNA P02545 1/20 0.31
▸ HPGDS O60760 1/20 0.31
▸ MAPT P10636 1/20 0.30
▸ TDP1 Q9NUW8 1/20 0.30
▸ TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6356661 0.88 DRD2 (0.34) ALDH1A1MAPTTDP1TSHR
SCHEMBL14206349 0.85 MAPT (0.30) ALDH1A1MAPTTDP1TSHR
SCHEMBL6356659 0.78 POLB (0.36) ALDH1A1LMNAMAPTTDP1
SCHEMBL19602569 0.71 ALDH1A1 (0.40) ALDH1A1LMNAMAPTTSHR
SCHEMBL436677 0.71 MEN1 (0.40) ALDH1A1LMNAMAPTTSHR
SCHEMBL8995838 0.71 POLB (0.40) ALDH1A1LMNAMAPTTSHR
SCHEMBL30004264 0.71 MEN1 (0.40) ALDH1A1LMNAMAPTTSHR
SCHEMBL1648090 0.68 MAPT (0.55) ALDH1A1LMNAMAPTTSHR
SCHEMBL9895961 0.66 HSD17B10 (0.32) ALDH1A1TDP1TSHR
SCHEMBL480144 0.66 TDP1 (0.44) ALDH1A1LMNAMAPTTDP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2051968-B1 LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES UNIV CALIFORNIA (US) 2020-04-29 — — EP disclosed
EP-2423201-B1 Luminescent macrocyclic lanthanide complexes UNIV CALIFORNIA (US) 2017-10-04 — — EP disclosed
US-8729258-B2 Luminescent macrocyclic lanthanide complexes THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-20 — — US disclosed
US-8729258-B2 Luminescent macrocyclic lanthanide complexes THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-05-20 — — US disclosed
US-20120329174-A1 LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-12-27 — — US disclosed
US-20120329174-A1 LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-12-27 — — US disclosed
US-8173800-B2 Hydroxy-isophthalamide moieties; antibodies; high stability, luminescence; kits THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-05-08 — — US disclosed
US-8173800-B2 Hydroxy-isophthalamide moieties; antibodies; high stability, luminescence; kits THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-05-08 — — US disclosed
US-20080213917-A1 LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-09-04 — — US disclosed
US-20080213917-A1 LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-09-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080213917-A1 LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES SSB, HACD3, CLTA ALDH1A1 4586/4885LMNA 2003/4885HPGDS 2128/4885
US-20120329174-A1 LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES SSB, HACD3, CLTA ALDH1A1 4586/4885LMNA 2003/4885HPGDS 2128/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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