Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28104610 | 0.85 | ALDH1A1 (0.50) | POLBKMT2AALDH1A1LMNAMAPT | |
| SCHEMBL29196257 | 0.82 | TSHR (0.59) | POLBKMT2AALDH1A1LMNAMAPT | |
| SCHEMBL16956118 | 0.81 | GABRA1 (0.43) | POLBKMT2AALDH1A1LMNAMRGPRX4 | |
| SCHEMBL537039 | 0.81 | ALDH1A1 (0.49) | ALDH1A1LMNAGABRA1GABRB2TSHR | |
| SCHEMBL20481943 | 0.80 | ALDH1A1 (0.47) | ALDH1A1LMNAGABRA1GABRB2TSHR | |
| SCHEMBL20482006 | 0.80 | ALDH1A1 (0.47) | ALDH1A1LMNAGABRA1GABRB2TSHR | |
| SCHEMBL20478154 | 0.80 | ALDH1A1 (0.47) | ALDH1A1LMNATSHRHTTCLCN2 | |
| SCHEMBL1648373 | 0.80 | MRGPRX4 (0.55) | KMT2AALDH1A1LMNAMRGPRX4GABRA1 | |
| SCHEMBL996244 | 0.79 | GABRA1 (0.40) | POLBKMT2AALDH1A1LMNAMRGPRX4 | |
| SCHEMBL6356661 | 0.79 | DRD2 (0.34) | POLBKMT2AALDH1A1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5554617-A | Method for treating cancer with 6-aryl pyrimidine compounds | THE UPJOHN COMPANY (US) | 1996-09-10 | — | — | US | disclosed |
| US-5434157-A | Active against herpes, hepatitis, papovavirus | THE UPJOHN COMPANY (US) | 1995-07-18 | — | — | US | disclosed |
| US-5002951-A | 2-amino-5-halo-4-pyrimidinol for bactericides and antiprotozoa agent | THE UPJOHN COMPANY (US) | 1991-03-26 | — | — | US | disclosed |
| US-4665077-A | IMMUNOREGULATORY AGENTS | THE UPJOHN COMPANY (US) | 1987-05-12 | — | — | US | disclosed |
| US-4619933-A | 6-aryl pyrimidines for treating aplastic anemia | THE UPJOHN COMPANY (US) | 1986-10-28 | — | — | US | disclosed |
| US-4507302-A | Method for treating arthritis with 6-aryl pyrimidine compounds | THE UPJOHN COMPANY (US) | 1985-03-26 | — | — | US | disclosed |