Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.74 |
| ▸ | MAP2 | P11137 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | XBP1 | P17861 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | CNR1 | P21554 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | PRSS12 | P56730 | 3/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.53 |
| ▸ | TUBB | P07437 | 2/20 | 0.53 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2735923 | 0.88 | ALDH1A1 (0.60) | ALDH1A1KDM4EMAP2MAPTPOLB | |
| SCHEMBL6353285 | 0.86 | GAA (0.72) | ALDH1A1KDM4EMAP2MAPTGAA | |
| SCHEMBL2735918 | 0.86 | ALDH1A1 (0.58) | ALDH1A1KDM4EMAP2MAPTPOLB | |
| SCHEMBL2735914 | 0.84 | MAP2 (0.59) | ALDH1A1KDM4EMAP2MAPTPOLB | |
| SCHEMBL2760048 | 0.83 | MAP2 (0.60) | ALDH1A1KDM4EMAP2MAPTPOLB | |
| SCHEMBL2735926 | 0.82 | MAP2 (0.62) | ALDH1A1KDM4EMAP2MAPTPOLB | |
| SCHEMBL18092612 | 0.82 | MEN1 (0.76) | ALDH1A1KDM4EMAPTPOLBGAA | |
| SCHEMBL2735904 | 0.81 | ALDH1A1 (0.60) | ALDH1A1KDM4EMAP2MAPTPOLB | |
| SCHEMBL42364 | 0.81 | MAP2 (1.00) | ALDH1A1KDM4EMAP2MAPTPOLB | |
| SCHEMBL8938481 | 0.80 | TUBB (0.53) | ALDH1A1KDM4EMAPTCNR1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040111-A2 | COMBINATORIAL LIBRARY OF 3-ARYL-1H-INDOLE-2-CARBOXYLIC ACIDS | F. HOFFMANN-LA ROCHE AG (DE) | 2005-05-06 | — | — | WO | disclosed |
| US-20050089936-A1 | Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid amides | CAI JIANPING (US) | 2005-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050089936-A1 | Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid amides | AADAC, KYNU, AANAT | ALDH1A1 104/4885KDM4E 2933/4885MAP2 96/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.