Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | MAP2 | P11137 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA6 | P23280 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6356091 | 0.86 | ALDH1A1 (0.74) | GAAKDM4EALDH1A1HPGDMAP2 | |
| SCHEMBL7566685 | 0.84 | GAA (1.00) | GAAKDM4EALDH1A1HPGDMAP2 | |
| SCHEMBL2735926 | 0.82 | MAP2 (0.62) | GAAKDM4EALDH1A1HPGDMAP2 | |
| SCHEMBL18092612 | 0.82 | MEN1 (0.76) | GAAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL2760048 | 0.81 | MAP2 (0.60) | GAAKDM4EALDH1A1MAP2SRC | |
| SCHEMBL2735930 | 0.80 | MAP2 (0.59) | GAAKDM4EALDH1A1HPGDMAP2 | |
| SCHEMBL9212419 | 0.79 | GAA (0.62) | GAAKDM4EALDH1A1HPGDMAP2 | |
| SCHEMBL2735915 | 0.79 | MAP2 (0.61) | GAAKDM4EALDH1A1HPGDMAP2 | |
| SCHEMBL2735923 | 0.79 | ALDH1A1 (0.60) | GAAKDM4EALDH1A1HPGDMAP2 | |
| SCHEMBL14081988 | 0.78 | MAP2 (0.57) | GAAKDM4EALDH1A1HPGDMAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040111-A2 | COMBINATORIAL LIBRARY OF 3-ARYL-1H-INDOLE-2-CARBOXYLIC ACIDS | F. HOFFMANN-LA ROCHE AG (DE) | 2005-05-06 | — | — | WO | disclosed |
| US-20050089936-A1 | Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid amides | CAI JIANPING (US) | 2005-04-28 | — | — | US | disclosed |
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050089936-A1 | Combinatorial library of 3-aryl-1H-indole-2-carboxylic acid amides | AADAC, KYNU, AANAT | GAA 3010/4885KDM4E 2933/4885ALDH1A1 104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.