Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | INMT | O95050 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8972811 | 1.00 | BLM (0.45) | BLMINMTLMNAALDH1A1TSHR | |
| Acrylic Acid SCHEMBL1405902 | 0.91 | LMNA (0.39) | BLMINMTLMNAALDH1A1TSHR | |
| Bicarbonate SCHEMBL28233410 | 0.90 | LMNA (0.39) | BLMINMTLMNAALDH1A1TSHR | |
| Hydrogen Peroxide SCHEMBL610401 | 0.90 | BRD4 (0.39) | BLMLMNAALDH1A1TSHRKMT2A | |
| Hydrogen Peroxide SCHEMBL2561887 | 0.90 | BRD4 (0.39) | BLMLMNAALDH1A1TSHRKMT2A | |
| Crotonic Acid SCHEMBL9316662 | 0.90 | BLM (0.38) | BLMINMTLMNAALDH1A1TSHR | |
| Crotonic Acid SCHEMBL5875704 | 0.90 | BLM (0.38) | BLMINMTLMNAALDH1A1TSHR | |
| Monomethyl Fumarate SCHEMBL11318420 | 0.88 | HCAR2 (0.49) | BLMINMTALDH1A1KMT2ACYP1A2 | |
| SCHEMBL28140603 | 0.87 | LMNA (0.35) | BLMINMTLMNAALDH1A1TSHR | |
| Acetic Acid SCHEMBL887070 | 0.87 | BRD4 (0.39) | BLMLMNAALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103038195-B | Device and method for solubilizing, separating, removing and reacting carboxylic acids in oils, fats, aqueous or organic solutions by micro-or nanoemulsification | ULRICH DIETZ (DE) | 2016-04-13 | — | — | CN | disclosed |
| US-20050284502-A1 | Rinse and resist patterning process using the same | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2005-12-29 | — | — | US | disclosed |
| US-5814694-A | INCLUDES A HOMO- OR COPOLYMER OF VINYLPYRROLIDONE, A FLUORINE-CONTAINING ORGANIC ACID AND AT LEAST ONE AMINO ACID DERIVATIVE TO DECREASE THE ACIDITY OF THE LAYER AND PREVENT DEACTIVATION OF ACIDS ON THE SURFACE | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1998-09-29 | — | — | US | disclosed |
| US-5529888-A | CONTAINING WATER SOLUBLE COPOLYMER OF N-VINYLPYRROLIDONE AND ANOTHER VINYL MONOMER, FLUORINATED ORGANIC ACID | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0363989-B1 | Thermal transfer image receiving materials | FUJI PHOTO FILM CO LTD (JP) | 1994-04-20 | — | — | EP | disclosed |
| US-5073533-A | Containing hardenable water soluble binder | FUJI PHOTO FILM CO., LTD. (JP) | 1991-12-17 | — | — | US | disclosed |
| US-4992414-A | Hydrophilic binder | FUJI PHOTO FILM CO., LTD. (JP) | 1991-02-12 | — | — | US | disclosed |
| EP-0363989-A2 | Thermal transfer image receiving materials | FUJI PHOTO FILM CO., LTD. (JP) | 1990-04-18 | — | — | EP | disclosed |
| EP-0338189-A2 | Method of producing affin-enzymatic compounds, for the visual detection of cholesterol on the surface of the skin of a patient, based on a detecting agent with an affinity for cholesterol and a visualisation agent | 2860601 Canada Inc. (CN) | 1989-10-25 | — | — | EP | disclosed |
| US-4622075-A | Metal cleaning | QO CHEMICALS, INC. (US) | 1986-11-11 | — | — | US | disclosed |