Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6796586 | 0.79 | HDAC1 (0.46) | HDAC1HDAC2GRIN2BDPP4SIGMAR1 | |
| SCHEMBL6363443 | 0.78 | ALDH1A1 (0.50) | HDAC1HDAC2KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL6363842 | 0.77 | GRIN2B (0.45) | ALDH1A1GRIN2BMEN1KMT2A | |
| SCHEMBL6356899 | 0.74 | ALDH1A1 (0.39) | HDAC1HDAC2KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL6359494 | 0.74 | KDM4E (0.55) | KDM4ESMN1; SMN2ALDH1A1TDP1GRIN2B | |
| SCHEMBL6358888 | 0.73 | KDM4E (0.46) | KDM4ESMN1; SMN2ALDH1A1TDP1GRIN2B | |
| SCHEMBL6795892 | 0.73 | ALDH1A1 (0.53) | KDM4ESMN1; SMN2ALDH1A1TDP1MEN1 | |
| SCHEMBL6358479 | 0.73 | HCRTR1 (0.56) | SMN1; SMN2ALDH1A1TDP1HTR2AHTR2C | |
| SCHEMBL19625647 | 0.68 | KDM4E (0.55) | KDM4ESMN1; SMN2ALDH1A1TDP1BCHE | |
| SCHEMBL20600701 | 0.67 | KDM4E (0.62) | KDM4ESMN1; SMN2ALDH1A1TDP1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234090-A1 | Modulators of chemokine receptor activity | PFIZER INC | 2005-10-20 | — | — | US | disclosed |
| US-6821964-B2 | FOR PROPHYLAXIS AND THERAPY OF DISEASES ASSOCIATED WITH MONOCYTE ACCUMULATION, LYMPHOCYTE ACCUMULATION OR LEUCOCYTE ACCUMULATION | PFIZER INC | 2004-11-23 | — | — | US | disclosed |
| EP-1368354-A1 | MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Pfizer Products Inc. (US) | 2003-12-10 | — | — | EP | disclosed |
| US-20030008893-A1 | Modulators of chemokine receptor activity | COLON-CRUZ ROBERTO (US) | 2003-01-09 | — | — | US | disclosed |
| WO-2002070523-A1 | MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | PFIZER PRODUCTS INC. (US) | 2002-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030008893-A1 | Modulators of chemokine receptor activity | CCR1, CCR3, CCR2 | HDAC1 1016/4885HDAC2 2160/4885KDM4E 4790/4885 |
| US-20050234090-A1 | Modulators of chemokine receptor activity | CCR3, CCR2, CCR1 | HDAC1 1190/4885HDAC2 2208/4885KDM4E 4766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.