Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 14/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6362541 | 0.91 | P2RX7 (0.57) | P2RX7TRPA1SIGMAR1KCNJ5KCNJ3 | |
| SCHEMBL6352684 | 0.82 | P2RX7 (0.50) | P2RX7TRPA1SIGMAR1 | |
| SCHEMBL6359743 | 0.82 | P2RX7 (0.49) | P2RX7TRPA1SIGMAR1 | |
| SCHEMBL6363240 | 0.80 | P2RX7 (0.51) | P2RX7TRPA1SIGMAR1 | |
| SCHEMBL6361632 | 0.78 | P2RX7 (0.63) | P2RX7TRPA1SIGMAR1 | |
| SCHEMBL6352873 | 0.78 | P2RX7 (0.48) | P2RX7TRPA1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6362383 | 0.77 | P2RX7 (0.48) | P2RX7TRPA1SIGMAR1 | |
| SCHEMBL6357779 | 0.77 | P2RX7 (0.60) | P2RX7TRPA1SIGMAR1 | |
| SCHEMBL6355091 | 0.76 | P2RX7 (0.65) | P2RX7TRPA1SIGMAR1 | |
| SCHEMBL6359746 | 0.75 | TSHR (0.49) | P2RX7TRPA1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009812-A1 | Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-01-13 | — | — | US | claimed |
| EP-1438973-A1 | REMEDIES FOR STRESS DISEASES COMPRISING MITOCHONDRIAL BENZODIAZEPINE RECEPTOR ANTAGONISTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-07-21 | — | — | EP | claimed |
| US-20050009812-A1 | Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-01-13 | — | — | US | disclosed |
| EP-1438973-A1 | REMEDIES FOR STRESS DISEASES COMPRISING MITOCHONDRIAL BENZODIAZEPINE RECEPTOR ANTAGONISTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-07-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009812-A1 | Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists | TFAM, CYP11B2, CYP11B1 | P2RX7 448/4885TRPA1 708/4885SIGMAR1 341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.