Gramine

Gramine

SCHEMBL63578

CN(C)Cc1c[nH]c2ccccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 1.00
KMT2A Q03164 5/20 1.00
MEN1 O00255 4/20 1.00
KDM4E B2RXH2 3/20 1.00
CYP3A4 P08684 3/20 1.00
HSD17B10 Q99714 2/20 1.00
CYP2D6 P10635 2/20 1.00
TSHR P16473 1/20 1.00
CYP2C19 P33261 1/20 1.00
MAPT P10636 4/20 0.69
HTR2A P28223 4/20 0.69
HTR2C P28335 4/20 0.69
HTR2B P41595 3/20 0.69
HTR1A P08908 3/20 0.69
HPGD P15428 1/20 0.69
LMNA P02545 3/20 0.68
GAA P10253 1/20 0.68
SLC6A4 P31645 2/20 0.65
AHR P35869 1/20 0.62
GPR84 Q9NQS5 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Gramine SCHEMBL29351803 1.00 ALDH1A1 (1.00) ALDH1A1KMT2AMEN1KDM4ECYP3A4
Gramine SCHEMBL9058128 0.98 ALDH1A1 (0.96) ALDH1A1KMT2AMEN1KDM4ECYP3A4
Gramine SCHEMBL7434281 0.96 ALDH1A1 (0.93) ALDH1A1KMT2AMEN1KDM4ECYP3A4
Gramine SCHEMBL20906415 0.87 ALDH1A1 (0.77) ALDH1A1KMT2AMEN1KDM4ECYP3A4
Gramine SCHEMBL8704815 0.85 ALDH1A1 (0.72) ALDH1A1KMT2AMEN1KDM4ECYP3A4
SCHEMBL947574 0.84 KMT2A (0.73) ALDH1A1KMT2AMEN1KDM4ECYP3A4
SCHEMBL22619123 0.84 ALDH1A1 (0.73) ALDH1A1KMT2AMEN1KDM4ECYP3A4
N,N-Dimethyltryptamine SCHEMBL335710 0.81 HTR2A (1.00) ALDH1A1KMT2AMEN1KDM4ECYP3A4
SCHEMBL1027348 0.81 ALDH1A1 (1.00) ALDH1A1KMT2AMEN1KDM4ECYP3A4
N,N-Dimethyltryptamine SCHEMBL29350959 0.81 HTR2A (1.00) ALDH1A1KMT2AMEN1KDM4ECYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1187 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260091067-A1 METHODS AND USES OF MICROBIOME COMPOSITIONS, COMPONENTS, OR METABOLITES FOR TREATING INSULIN-ASSOCIATED DISEASES MARVELBIOME INC (US) 2026-04-02 US claimed
WO-2025262555-A1 SECURE COMMUNICATION SYSTEMS AND METHODS FOR GPU ACCELERATION IN TRUSTED EXECUTION ENVIRONMENTS MODELYO TECHNOLOGIES LTD (IL) 2025-12-26 WO claimed
EP-4624483-A1 GRAMINE-PLATINUM (IV) COMPLEX AS WELL AS PREPARATION METHOD THEREFOR AND ANTI-TUMOR USE THEREOF Tianjin Medical University Cancer Institute and Hospital (CN) 2025-10-01 EP claimed
US-20250243345-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE TOYO TIRE CORPORATION (JP) 2025-07-31 US claimed
US-20250243350-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE TOYO TIRE CORPORATION (JP) 2025-07-31 US claimed
EP-4587116-A2 METHODS AND USES OF MICROBIOME COMPOSITIONS, COMPONENTS, OR METABOLITES FOR TREATING INSULIN-ASSOCIATED DISEASES MarvelBiome, Inc. (US) 2025-07-23 EP claimed
WO-2025054048-A1 METHODS AND USES OF MICROBIOME COMPOSITIONS, COMPONENTS, OR METABOLITES FOR TREATING LIPID AND CHOLESTEROL METABOLISM ASSOCIATED DISEASES, DISORDERS, AND CONDITIONS MarvelBiome, Inc. (US) 2025-03-13 WO claimed
EP-4456723-A1 ANTIMICROBIAL SYSTEM WITH BETA CARBOLINE ALKALOID AND INDOLE ALKALOID AND COMPOSITIONS COMPRISING THEM Unilever IP Holdings B.V. (NL) 2024-11-06 EP claimed
EP-4440342-A1 METHODS AND USES OF MICROBIOME COMPOSITIONS, COMPONENTS, OR METABOLITES FOR TREATING VAGUS NERVE ASSOCIATED DISEASES, DISORDERS, AND CONDITIONS MarvelBiome, Inc. (US) 2024-10-09 EP claimed
EP-4401745-A1 METHODS AND USES OF MICROBIOME COMPOSITIONS, COMPONENTS, OR METABOLITES FOR TREATING NEURODEGENERATIVE DISEASES MarvelBiome, Inc. (US) 2024-07-24 EP claimed
US-6106599-A Inks XEROX CORPORATION (US) 2000-08-22 US claimed
CN-1202182-A Curable compositions SMITH & NEPHEW (GB) 1998-12-16 CN claimed
EP-0850256-A1 CURABLE COMPOSITIONS Smith & Nephew plc (GB) 1998-07-01 EP claimed
WO-1997010275-A1 CURABLE COMPOSITIONS SMITH & NEPHEW PLC (GB) 1997-03-20 WO claimed
EP-0598022-B1 PROCESS FOR WETTING GRAIN WITH A LIQUID AND DEVICE FOR IMPLEMENTING THE PROCESS AND THE APPLICATION OF THE PROCESS GRAEF DIETER OTTO (DE) 1995-05-24 EP claimed
US-5210215-A Reacting indoles, dimethylamine and formaldehyde to gramines, condensing with malonic compounds to tryptophans, converting to 3-indolepyruvic acids; also preparation from indoles by reaction with alkyl ester oximes of 3-bromopyruvic acid POLIFARMA S.P.A. (IT) 1993-05-11 US claimed
EP-0421946-A2 3-indolepyruvic acid derivatives their method of production and therapeutic use POLIFARMA S.p.A. (IT) 1991-04-10 EP claimed
EP-0037271-B1 INDOLE DERIVATIVES AND PROCESS FOR PREPARING THE SAME TORAY INDUSTRIES, INC. (JP) 1984-01-18 EP claimed
EP-0037271-A1 Indole derivatives and process for preparing the same TORAY INDUSTRIES, INC. (JP) 1981-10-07 EP claimed
US-3997539-A HYPOTENSIVE, TRANQUILIZER AMERICAN HOECHST CORPORATION (US) 1976-12-14 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260091067-A1 METHODS AND USES OF MICROBIOME COMPOSITIONS, COMPONENTS, OR METABOLITES FOR TREATING INSULIN-ASSOCIATED DISEASES IAPP, GPR119, FAHD1 ALDH1A1 1370/4885KMT2A 2945/4885MEN1 361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.