Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | IL15 | P40933 | 2/20 | 0.35 |
| ▸ | IL15RA | Q13261 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 6/20 | 0.34 |
| ▸ | DRD3 | P35462 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14277204 | 0.90 | MAPK1 (0.49) | MAPK1MEN1KMT2AALDH1A1HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL6357623 | 0.87 | ALDH1A1 (0.36) | MAPK1MEN1KMT2AALDH1A1HSD11B1 | |
| SCHEMBL5095806 | 0.83 | MEN1 (0.49) | MAPK1MEN1KMT2AALDH1A1HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL6356669 | 0.80 | HSD11B1 (0.44) | MAPK1MEN1KMT2AALDH1A1HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL6354775 | 0.80 | HSD11B1 (0.43) | MAPK1MEN1KMT2AALDH1A1HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL5092182 | 0.76 | MEN1 (0.46) | MAPK1MEN1KMT2AALDH1A1HSD11B1 | |
| SCHEMBL14277203 | 0.75 | HSD11B1 (0.37) | MAPK1MEN1KMT2AALDH1A1HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL5092061 | 0.74 | ALDH1A1 (0.40) | MAPK1MEN1KMT2AALDH1A1HSD11B1 | |
| SCHEMBL2667476 | 0.73 | MEN1 (0.53) | MAPK1MEN1KMT2AALDH1A1HSD11B1 | |
| SCHEMBL5098587 | 0.72 | MAPK1 (0.47) | MAPK1MEN1KMT2AALDH1A1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050070720-A1 | 11-Beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | MERCK SHARP & DOHME CORP. | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070720-A1 | 11-Beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia | HSD11B1, HSD17B1, HSD11B2 | MAPK1 358/4885MEN1 2285/4885KMT2A 2645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.