Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR1 | P47211 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GALR2 | O43603 | 4/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | BPTF | Q12830 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6359862 | 1.00 | GALR1 (0.40) | GALR1LMNAMAPTGALR2GBA1 | |
| SCHEMBL6359861 | 0.75 | MAPT (0.48) | GALR1LMNAMAPTGALR2GBA1 | |
| SCHEMBL3240588 | 0.72 | GALR2 (0.59) | GALR1LMNAMAPTGALR2GBA1 | |
| SCHEMBL6359088 | 0.66 | ROCK2 (0.35) | — | |
| SCHEMBL3241392 | 0.66 | GALR2 (0.59) | GALR1LMNAMAPTGALR2SMN1; SMN2 | |
| SCHEMBL3240980 | 0.64 | GALR2 (0.62) | GALR1LMNAMAPTGALR2 | |
| SCHEMBL18153416 | 0.64 | CASP1 (0.61) | GALR1LMNAMAPTGALR2BPTF | |
| SCHEMBL3245932 | 0.64 | GALR2 (0.61) | GALR1LMNAMAPTGALR2GBA1 | |
| SCHEMBL18153355 | 0.63 | LMNA (0.69) | GALR1LMNAMAPTGALR2BPTF | |
| SCHEMBL3246321 | 0.63 | CASP1 (0.59) | GALR1LMNAMAPTGALR2BPTF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936607-B2 | 2,4,6-Triaminopyrimidines for the treatment of depression and/or anxiety | H. LUNOBECK A/S (DK) | 2005-08-30 | — | — | US | disclosed |