Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6361067 | 0.92 | MAPT (0.44) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6361049 | 0.85 | TDP1 (0.53) | MAPTLMNAALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL26843498 | 0.82 | TDP1 (0.46) | MAPTLMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7483591 | 0.78 | ALDH1A1 (0.48) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL5007542 | 0.77 | CASP3 (0.50) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6360532 | 0.73 | RAD52 (0.46) | MAPTLMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL6360527 | 0.71 | RAD52 (0.47) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL7483599 | 0.69 | MPO (0.38) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6361695 | 0.67 | NQO2 (0.42) | MAPTALDH1A1KDM4ETDP1 | |
| SCHEMBL746722 | 0.67 | ALDH1A1 (0.56) | MAPTLMNAALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009830-A1 | Heterocyclic cytotoxic agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY. | 2005-01-13 | — | — | US | claimed |
| US-6740650-B2 | SUCH AS 2,3-DIMETHOXY-DIBENZO(C,H)CINNOLINE FOR TREATMENT OF CANCER; FUNGICIDES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2004-05-25 | — | — | US | claimed |
| US-20030100560-A1 | Heterocyclic cytotoxic agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2003-05-29 | — | — | US | claimed |
| EP-1228045-A2 | HETEROCYCLIC CYTOTOXIC AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2002-08-07 | — | — | EP | claimed |
| WO-2001032631-A2 | HETEROCYCLIC CYTOTOXIC AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JEREY (US) | 2001-05-10 | — | — | WO | claimed |
| US-20050009830-A1 | Heterocyclic cytotoxic agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY. | 2005-01-13 | — | — | US | disclosed |
| US-6740650-B2 | SUCH AS 2,3-DIMETHOXY-DIBENZO(C,H)CINNOLINE FOR TREATMENT OF CANCER; FUNGICIDES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2004-05-25 | — | — | US | disclosed |
| US-20030100560-A1 | Heterocyclic cytotoxic agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2003-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009830-A1 | Heterocyclic cytotoxic agents | CCNE1, RB1, CCNA1 | MAPT 4872/4885LMNA 1515/4885ALDH1A1 345/4885 |
| US-20030100560-A1 | Heterocyclic cytotoxic agents | CCNA1, CCNE1, MCL1 | MAPT 4835/4885LMNA 1211/4885ALDH1A1 114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.