Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 20/20 | 0.65 |
| ▸ | CTSS | P25774 | 18/20 | 0.65 |
| ▸ | CTSK | P43235 | 17/20 | 0.65 |
| ▸ | CTSB | P07858 | 14/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2156323 | 0.87 | CTSL (0.79) | CTSLCTSSCTSKCTSB | |
| SCHEMBL6364256 | 0.82 | CTSL (0.77) | CTSLCTSSCTSKCTSB | |
| SCHEMBL4677118 | 0.81 | CTSL (0.66) | CTSLCTSSCTSKCTSB | |
| SCHEMBL2157281 | 0.79 | CTSL (1.00) | CTSLCTSSCTSKCTSB | |
| SCHEMBL6364532 | 0.78 | CTSL (0.81) | CTSLCTSSCTSKCTSB | |
| SCHEMBL2156540 | 0.77 | CTSL (1.00) | CTSLCTSSCTSKCTSB | |
| SCHEMBL2156626 | 0.77 | CTSL (1.00) | CTSLCTSSCTSKCTSB | |
| SCHEMBL2157417 | 0.76 | CTSL (1.00) | CTSLCTSSCTSKCTSB | |
| SCHEMBL2155543 | 0.76 | CTSL (0.76) | CTSLCTSSCTSKCTSB | |
| SCHEMBL2155836 | 0.76 | CTSL (1.00) | CTSLCTSSCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050240023-A1 | N1-(1-cyanocyclopropyl)-4-fluoro-N2-{(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)-1,1'-biphenyl-4-yl]ethyl}-L-leucinamide; osteoporosis and other bone loss disorders | MERCK CANADA INC. (CA) | 2005-10-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050240023-A1 | N1-(1-cyanocyclopropyl)-4-fluoro-N2-{(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)-1,1'-biphenyl-4-yl]ethyl}-L-leucinamide; osteoporosis and other bone loss disorders | CTSE, CTSS, CTSB | CTSL 7/4885CTSS 2/4885CTSK 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.