Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.34 |
| ▸ | ABAT | P80404 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6779438 | 0.82 | ALDH1A1 (0.39) | ALDH1A1ADRB2ADRB1ADRB3CYP2A6 | |
| SCHEMBL498799 | 0.81 | ALDH1A1 (0.41) | ALDH1A1ADRB2ADRB1ADRB3CYP2A6 | |
| SCHEMBL12426830 | 0.80 | ALDH1A1 (0.41) | ALDH1A1ADRB2ADRB1ADRB3SMN1; SMN2 | |
| SCHEMBL3285117 | 0.80 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2NPC1RAB9ARECQL | |
| SCHEMBL6364681 | 0.80 | ALDH1A1 (0.48) | ALDH1A1ADRB2ADRB1ADRB3CYP2A6 | |
| SCHEMBL2818700 | 0.79 | MAPT (0.42) | ALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL2823545 | 0.76 | CA1 (0.44) | ALDH1A1SMN1; SMN2RAB9AKDM4EMAPT | |
| SCHEMBL4877710 | 0.76 | LOXL2 (0.40) | ABATSMN1; SMN2KDM4ETBXAS1EPHX2 | |
| SCHEMBL4884087 | 0.76 | SLC22A12 (0.44) | ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL4927261 | 0.75 | LOXL2 (0.39) | ABATSMN1; SMN2KDM4ETBXAS1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130150325-A1 | 3-(Fluorovinyl)pyrazoles and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-06-13 | — | — | US | disclosed |
| US-20050154061-A1 | peroxisome-proliferator-activated receptor (PPAR)-delta agonist; 2-[4-[[[2-[(2,4-Dichlorophenyl)amino]-2-oxoethyl]cyclohexylamino]methyl]-2-methylphenoxy]-2-methylpropanoic acid; cardiovascular disorders, dyslipidaemias or restenosis; improves HDL/LDL cholesterol ratio; side effect reduction | BAYER AKTIENGESELLSCHAFT (DE) | 2005-07-14 | — | — | US | disclosed |
| US-20040176445-A1 | Propionic acid derivatives | BAYER PHARMACEUTICALS CORPORATION | 2004-09-09 | — | — | US | disclosed |
| EP-1438285-A1 | ACETIC ACID DERIVATIVES | Bayer HealthCare AG (DE) | 2004-07-21 | — | — | EP | disclosed |
| US-6750236-B2 | CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 2004-06-15 | — | — | US | disclosed |
| US-20030187041-A1 | Propionic acid derivatives | URBAHNS KLAUS (DE) | 2003-10-02 | — | — | US | disclosed |
| EP-1328508-A2 | PROPIONIC ACID DERIVATIVES WITH PPAR-ALPHA ACTIVATING PROPERTIES | Bayer Aktiengesellschaft (DE) | 2003-07-23 | — | — | EP | disclosed |
| WO-2003035603-A1 | ACETIC ACID DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-05-01 | — | — | WO | disclosed |
| US-6548538-B2 | Potent peroxisome proliferator activated receptor (PPAR)-alpha-activating compounds; propionic acid 2-subsituted with an N-(phenylaminocarbonylalkyl), N-(2-furanylmethyl)aminoalkylphenyl group | BAYER AKTIENGESELLSCHAFT (DE) | 2003-04-15 | — | — | US | disclosed |
| US-20030032671-A1 | Propionic acid derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2003-02-13 | — | — | US | disclosed |
| WO-2002028821-A2 | PROPIONIC ACID DERIVATIVES WITH PPAR-ALPHA ACTIVATING PROPERTIES | BAYER AKTIENGESELLSCHAFT (DE) | 2002-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187041-A1 | Propionic acid derivatives | PPARA, PPARD, PPARG | ALDH1A1 257/4885ADRB2 43/4885ADRB1 14/4885 |
| US-20030032671-A1 | Propionic acid derivatives | PPARD, PPARA, PPARG | ALDH1A1 550/4885ADRB2 38/4885ADRB1 11/4885 |
| US-20130150325-A1 | 3-(Fluorovinyl)pyrazoles and their use | VHL, HIF1AN, HIF1A | ALDH1A1 721/4885ADRB2 1375/4885ADRB1 1859/4885 |
| US-20050154061-A1 | peroxisome-proliferator-activated receptor (PPAR)-delta agonist; 2-[4-[[[2-[(2,4-Dichlorophenyl)amino]-2-oxoethyl]cyclohexylamino]methyl]-2-methylphenoxy]-2-methylpropanoic acid; cardiovascular disorders, dyslipidaemias or restenosis; improves HDL/LDL cholesterol ratio; side effect reduction | PPARA, PPARD, PPARG | ALDH1A1 639/4885ADRB2 22/4885ADRB1 13/4885 |
| US-20040176445-A1 | Propionic acid derivatives | PPARD, PPARA, PPARG | ALDH1A1 550/4885ADRB2 38/4885ADRB1 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.