Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 11/20 | 0.46 |
| ▸ | CCND1 | P24385 | 9/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.42 |
| ▸ | CTSK | P43235 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CCND3 | P30281 | 3/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 5/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1991171 | 0.85 | CDK4 (0.50) | CDK4CCND1CDK2CCND3CDK6 | |
| SCHEMBL22174830 | 0.85 | CDK4 (0.49) | CDK4CCND1CDK2CCND3CDK6 | |
| SCHEMBL19711678 | 0.84 | CDK4 (0.51) | CDK4CCND1CDK2CCND3CDK6 | |
| SCHEMBL31106627 | 0.81 | CDK4 (0.53) | CDK4CCND1CDK2CCND3CDK6 | |
| SCHEMBL29988033 | 0.81 | CDK4 (0.67) | CDK4CCND1CDK2CCND3CDK6 | |
| SCHEMBL31372001 | 0.81 | CDK4 (0.53) | CDK4CCND1CDK2CCND3CDK6 | |
| SCHEMBL1988950 | 0.81 | CDK4 (0.52) | CDK4CCND1CDK2CCND3CDK6 | |
| SCHEMBL1990321 | 0.81 | CDK4 (0.67) | CDK4CCND1CDK2CCND3CDK6 | |
| SCHEMBL20425411 | 0.81 | CDK4 (0.53) | CDK4CCND1CDK2CCND3CDK6 | |
| SCHEMBL2301318 | 0.80 | CDK4 (0.69) | CDK4CCND1CDK2CCND3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3753933-A1 | SUCCINATE SALT OF 7-CYCLOPENTYL-2 -(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF | Novartis AG (CH) | 2020-12-23 | — | — | EP | disclosed |
| US-9868739-B2 | Salt(s) of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and processes of making thereof | NOVARTIS AG (CH) | 2018-01-16 | — | — | US | disclosed |
| US-9868739-B2 | Salt(s) of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and processes of making thereof | NOVARTIS AG (CH) | 2018-01-16 | — | — | US | disclosed |
| US-20160039832-A1 | SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF | NOVARTIS AG (CH) | 2016-02-11 | — | — | US | disclosed |
| US-9193732-B2 | Salt(s) of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-D]pyrimidine-6-carboxylic acid dimethylamide and processes of making thereof | NOVARTIS AG (CH) | 2015-11-24 | — | — | US | disclosed |
| US-9193732-B2 | Salt(s) of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-D]pyrimidine-6-carboxylic acid dimethylamide and processes of making thereof | NOVARTIS AG (CH) | 2015-11-24 | — | — | US | disclosed |
| US-20150099760-A1 | SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF | NOVARTIS AG (CH) | 2015-04-09 | — | — | US | disclosed |
| US-20130217698-A1 | SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF | ASTEX THERAPEUTICS LTD (GB) | 2013-08-22 | — | — | US | disclosed |
| US-20130217698-A1 | SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF | ASTEX THERAPEUTICS LTD (GB) | 2013-08-22 | — | — | US | disclosed |
| WO-2012064805-A1 | SALT(S) OF 7-CYCLOPENTYL-2 -(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF | NOVARTIS AG (CH) | 2012-05-18 | — | — | WO | disclosed |
| US-20120115878-A1 | SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF | CALIENNI JOHN VINCENT (US) | 2012-05-10 | — | — | US | disclosed |
| US-20120115878-A1 | SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF | CALIENNI JOHN VINCENT (US) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099760-A1 | SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF | PKD2, SLC6A7, DHPS | CDK4 2373/4885CCND1 4058/4885CTSS 2610/4885 |
| US-20160039832-A1 | SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF | PKD2, DHPS, SRM | CDK4 2284/4885CCND1 3904/4885CTSS 2326/4885 |
| US-20130217698-A1 | SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF | PKD2, SLC6A7, DHPS | CDK4 2373/4885CCND1 4058/4885CTSS 2610/4885 |
| US-20120115878-A1 | SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF | PKD2, SLC6A7, DHPS | CDK4 2373/4885CCND1 4058/4885CTSS 2610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.