Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | GALR2 | O43603 | 1/20 | 0.49 |
| ▸ | GALR1 | P47211 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7055546 | 0.98 | NPC1 (0.58) | HTTNPC1RAB9AGALR2GALR1 | |
| SCHEMBL28470521 | 0.85 | SMN1; SMN2 (0.58) | HTTNPC1RAB9ACYP2C19POLB | |
| SCHEMBL3544482 | 0.79 | POLB (0.44) | HTTRAB9ACYP2C19MEN1KMT2A | |
| SCHEMBL19858912 | 0.75 | NPC1 (0.51) | HTTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8989442 | 0.75 | ALDH1A1 (0.55) | HTTNPC1RAB9ACYP2C19MEN1 | |
| SCHEMBL7102415 | 0.75 | CHRNB2 (0.44) | HTTNPC1RAB9AGALR2 | |
| SCHEMBL3183663 | 0.74 | NPC1 (0.55) | HTTNPC1RAB9AKMT2AHRH3 | |
| SCHEMBL7097803 | 0.73 | SCN10A (0.44) | HTTNPC1RAB9AGALR2HRH3 | |
| SCHEMBL7103744 | 0.73 | SCN10A (0.44) | HTTNPC1RAB9AGALR2HRH3 | |
| SCHEMBL10405943 | 0.73 | GALR2 (0.63) | HTTNPC1RAB9AGALR2GALR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050288324-A1 | Aromatic sulfonamides as peroxynitrite-rearrangement catalysts | BLUME THORSTEN | 2005-12-29 | — | — | US | disclosed |
| US-6946466-B2 | Aromatic sulfonamides as peroxynitrite-rearrangement catalysts | SCHERING AG (DE) | 2005-09-20 | — | — | US | disclosed |
| WO-2004089882-A2 | AROMATIC SULFONAMIDES AS PEROXYNITRITE-REARRANGEMENT CATALYSTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2004-10-21 | — | — | WO | disclosed |
| US-20040204452-A1 | Aromatic sulfonamides as peroxynitrite-rearrangement catalysts | SCHERING AG (DE) | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288324-A1 | Aromatic sulfonamides as peroxynitrite-rearrangement catalysts | SQOR, GSR, PPOX | HTT 1708/4885NPC1 3149/4885RAB9A 4481/4885 |
| US-20040204452-A1 | Aromatic sulfonamides as peroxynitrite-rearrangement catalysts | SQOR, NOX1, GSR | HTT 1497/4885NPC1 2309/4885RAB9A 4403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.