Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27382642 | 0.72 | HRH3 (0.39) | CYP1A2CYP2D6CYP2C19SMN1; SMN2HIF1A | |
| SCHEMBL10891765 | 0.72 | LTA4H (0.49) | CYP1A2CYP2D6CYP2C19SMN1; SMN2HIF1A | |
| SCHEMBL5289989 | 0.70 | LTA4H (0.50) | CYP1A2CYP2D6CYP2C19SMN1; SMN2HIF1A | |
| SCHEMBL18205869 | 0.68 | PTGER4 (0.46) | CYP1A2CYP2D6CYP2C19CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL9850513 | 0.68 | CYP1A2 (0.48) | CYP1A2SMN1; SMN2PIM1HTR1AADRA1B | |
| SCHEMBL19283157 | 0.68 | ACP1 (0.64) | ACP1 | |
| SCHEMBL27356338 | 0.68 | CYP1A2 (0.40) | CYP1A2CYP2D6CYP2C19SMN1; SMN2HIF1A | |
| SCHEMBL23022845 | 0.67 | POLB (0.59) | POLBKMT2A | |
| SCHEMBL11969837 | 0.67 | METAP2 (0.43) | CYP1A2CYP2D6CYP2C19SMN1; SMN2HIF1A | |
| SCHEMBL11450303 | 0.65 | SLC6A2 (0.49) | CYP1A2CYP2D6CYP2C19POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178953-B1 | AROMATIC AMIDES | WARNER LAMBERT CO (US) | 2003-12-03 | — | — | EP | claimed |
| JP-2002544186-A | — | — | 2002-12-24 | — | — | JP | claimed |
| CN-1352631-A | Aromatic amides | WARNER LAMBERT CO (US) | 2002-06-05 | — | — | CN | claimed |
| EP-1178953-A1 | AROMATIC AMIDES | WARNER-LAMBERT COMPANY (US) | 2002-02-13 | — | — | EP | claimed |
| WO-2000068184-A1 | AROMATIC AMIDES | WARNER-LAMBERT COMPANY (US) | 2000-11-16 | — | — | WO | claimed |
| US-6846953-B1 | Aromatic amides | WARNER LAMBERT COMPANY (US) | 2005-01-25 | — | — | US | disclosed |