Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6219428 | 0.88 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11HTR3A | |
| SCHEMBL6370938 | 0.85 | HTR3A (0.56) | MAPK14MAPK13MAPK12MAPK11HTR3A | |
| SCHEMBL6218867 | 0.85 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11HTR3A | |
| SCHEMBL6371556 | 0.80 | MAPK14 (0.45) | MAPK14MAPK13MAPK12MAPK11HTR3A | |
| SCHEMBL6275690 | 0.73 | HTR3A (0.53) | MAPK14MAPK13MAPK12MAPK11HTR3A | |
| SCHEMBL6371003 | 0.73 | HTR3A (0.53) | MAPK14MAPK13MAPK12MAPK11HTR3A | |
| SCHEMBL6963796 | 0.68 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL7850580 | 0.67 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11HTR3A | |
| SCHEMBL7853648 | 0.67 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11HTR3A | |
| SCHEMBL27608558 | 0.66 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043331-A1 | Substituted 3-(2,5-disubstituted)pyridyl-4-aryl pyrroles for treating inflammatory diseases | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043331-A1 | Substituted 3-(2,5-disubstituted)pyridyl-4-aryl pyrroles for treating inflammatory diseases | TNF, TSLP, IRAK1 | MAPK14 240/4885MAPK13 118/4885MAPK12 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.