Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 6/20 | 1.00 |
| ▸ | MMP13 | P45452 | 2/20 | 0.69 |
| ▸ | MMP3 | P08254 | 1/20 | 0.69 |
| ▸ | MMP9 | P14780 | 1/20 | 0.69 |
| ▸ | MMP8 | P22894 | 1/20 | 0.69 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.53 |
| ▸ | GSK3B | P49841 | 4/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.53 |
| ▸ | AKT1 | P31749 | 4/20 | 0.53 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.53 |
| ▸ | NEK4 | P51957 | 3/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.53 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.53 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.53 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.53 |
| ▸ | GSK3A | P49840 | 3/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6388969 | 0.99 | MMP12 (0.98) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6388429 | 0.88 | MMP12 (0.78) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6370866 | 0.87 | MMP12 (1.00) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6370577 | 0.83 | MMP12 (1.00) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL8298104 | 0.81 | MMP12 (1.00) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL4321262 | 0.81 | MMP12 (1.00) | MMP12MMP13MMP3MMP9MMP8 | |
| Hydrochloric Acid SCHEMBL6662154 | 0.81 | MMP12 (0.98) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6369688 | 0.80 | MMP12 (0.87) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6370523 | 0.76 | MMP12 (1.00) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6388987 | 0.76 | MMP12 (0.79) | MMP12MMP13MMP3MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014817-A1 | Fluorothiophene derivatives, process for preparing them and pharmaceutical compositions containing them | PFIZER INC | 2005-01-20 | — | — | US | disclosed |
| EP-1493740-A1 | 5-fluoro-thiophene compounds, the process for their prepartion, the pharmaceutical compositions containing them and their use as metalloproteinases inhibitors | Warner-Lambert Company LLC (US) | 2005-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014817-A1 | Fluorothiophene derivatives, process for preparing them and pharmaceutical compositions containing them | MMP12, MMP13, MMP11 | MMP12 1/4885MMP13 2/4885MMP3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.