Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 8/20 | 1.00 |
| ▸ | MMP13 | P45452 | 2/20 | 0.48 |
| ▸ | DCAF1 | Q9Y4B6 | 8/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGAV | P06756 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6370577 | 0.93 | MMP12 (1.00) | MMP12MMP13ITGB3ITGAVPDE2A | |
| SCHEMBL6371578 | 0.91 | MMP12 (0.86) | MMP12MMP13DCAF1ITGB3ITGAV | |
| SCHEMBL6371574 | 0.88 | MMP12 (0.80) | MMP12MMP13DCAF1ITGB3ITGAV | |
| SCHEMBL6141819 | 0.82 | MMP12 (0.71) | MMP12MMP13DCAF1ITGB3ITGAV | |
| SCHEMBL6369688 | 0.82 | MMP12 (0.87) | MMP12MMP13DCAF1MMP3MMP9 | |
| SCHEMBL6369840 | 0.76 | MMP12 (1.00) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6367899 | 0.75 | MMP12 (0.73) | MMP12MMP13ITGB3ITGAVPDE2A | |
| Hydrochloric Acid SCHEMBL6388969 | 0.75 | MMP12 (0.98) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6370866 | 0.75 | MMP12 (1.00) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6378030 | 0.75 | MMP12 (0.59) | MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014817-A1 | Fluorothiophene derivatives, process for preparing them and pharmaceutical compositions containing them | PFIZER INC | 2005-01-20 | — | — | US | disclosed |
| EP-1493740-A1 | 5-fluoro-thiophene compounds, the process for their prepartion, the pharmaceutical compositions containing them and their use as metalloproteinases inhibitors | Warner-Lambert Company LLC (US) | 2005-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014817-A1 | Fluorothiophene derivatives, process for preparing them and pharmaceutical compositions containing them | MMP12, MMP13, MMP11 | MMP12 1/4885MMP13 2/4885DCAF1 3654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.