Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tilarginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 known ✓ | P35228 | 5/20 | 0.46 |
| ▸ | NOS3 known ✓ | P29474 | 4/20 | 0.46 |
| ▸ | NOS1 known ✓ | P29475 | 4/20 | 0.46 |
| ▸ | OTC | P00480 | 1/20 | 0.51 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.44 |
| ▸ | GSR | P00390 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | ARG2 | P78540 | 4/20 | 0.41 |
| ▸ | ARG1 | P05089 | 3/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tilarginine SCHEMBL315843 | 1.00 | OTC (0.51) | OTCNOS2NOS3NOS1DDAH1 | |
| Tilarginine SCHEMBL12028766 | 1.00 | OTC (0.51) | OTCNOS2NOS3NOS1DDAH1 | |
| Tilarginine SCHEMBL2229626 | 0.98 | OTC (0.50) | OTCNOS2NOS3NOS1DDAH1 | |
| Tilarginine SCHEMBL1321022 | 0.97 | OTC (0.49) | OTCNOS2NOS3NOS1DDAH1 | |
| SCHEMBL1006081 | 0.95 | GSR (0.47) | OTCNOS2NOS3NOS1DDAH1 | |
| SCHEMBL14423587 | 0.95 | GSR (0.47) | OTCNOS2NOS3NOS1DDAH1 | |
| SCHEMBL4393876 | 0.89 | PMP22 (0.43) | OTCNOS2NOS3NOS1GSR | |
| SCHEMBL29533865 | 0.89 | PMP22 (0.43) | OTCNOS2NOS3NOS1GSR | |
| SCHEMBL19608041 | 0.86 | DPP7 (0.41) | OTCNOS2NOS3NOS1DDAH1 | |
| SCHEMBL12279136 | 0.86 | DPP7 (0.41) | OTCNOS2NOS3NOS1DDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077129-B1 | CLEANING FORMULATION FOR REMOVING RESIDUES ON SURFACES | FUJIFILM ELECTRONIC MAT USA INC (US) | 2020-11-11 | — | — | EP | claimed |
| US-12275921-B2 | Treatment liquid and substrate treatment method | FUJIFILM CORPORATION (JP) | 2025-04-15 | — | — | US | disclosed |
| US-20240400949-A1 | COMPOSITION, COMPOUND, RESIN, SUBSTRATE TREATMENT METHOD, AND MANUFACTURING METHOD FOR SEMICONDUCTOR DEVICE | FUJIFILM CORPORATION (JP) | 2024-12-05 | — | — | US | disclosed |
| EP-3719105-B1 | CLEANING FORMULATION FOR REMOVING RESIDUES ON SURFACES | FUJIFILM ELECTRONIC MAT USA INC (US) | 2023-09-27 | — | — | EP | disclosed |
| US-20230287304-A1 | TREATMENT LIQUID AND SUBSTRATE TREATMENT METHOD | FUJIFILM CORPORATION (JP) | 2023-09-14 | — | — | US | disclosed |
| US-11639487-B2 | Cleaning formulation for removing residues on surfaces | FUJIFILM ELECTRONIC MATERIALS U.S.A., INC. (US) | 2023-05-02 | — | — | US | disclosed |
| US-11618867-B2 | Cleaning formulation for removing residues on surfaces | FUJIFILM ELECTRONIC MATERIALS U.S.A., INC. (US) | 2023-04-04 | — | — | US | disclosed |
| US-20230100080-A1 | CLEANING FORMULATION FOR REMOVING RESIDUES ON SURFACES | FUJIFILM ELECTRONIC MATERIALS U.S.A., INC. | 2023-03-30 | — | — | US | disclosed |
| US-20230066300-A1 | CLEANING FORMULATION FOR REMOVING RESIDUES ON SURFACES | FUJIFILM ELECTRONIC MATERIALS U.S.A., INC. | 2023-03-02 | — | — | US | disclosed |
| US-20220275313-A1 | CLEANING FORMULATION FOR REMOVING RESIDUES ON SURFACES | FUJIFILM ELECTRONIC MATERIALS U.S.A., INC. | 2022-09-01 | — | — | US | disclosed |
| US-11286444-B2 | Cleaning formulation for removing residues on surfaces | FUJIFILM ELECTRONIC MATERIALS U.S.A., INC. (US) | 2022-03-29 | — | — | US | disclosed |
| US-7253194-B2 | Compounds and inhibitors of phospholipases | THE UNIVERSITY OF QUEENSLAND (AU) | 2007-08-07 | — | — | US | disclosed |
| US-6858396-B2 | Positively charged non-natural amino acids, methods of making and using thereof in peptides | MEDICAL UNIVERSITY OF SOUTH CAROLINA (US) | 2005-02-22 | — | — | US | disclosed |
| US-6783946-B2 | CLOSELY REPLICATE THE NATURAL AMINO ACIDS LYSINE AND ARGININE. | MEDICAL UNIVERSITY OF SOUTH CAROLINA | 2004-08-31 | — | — | US | disclosed |
| US-6566330-B1 | As chemical intermediate | MEDICAL UNIVERSITY OF SOUTH CAROLINA FOUNDATION RESEARCH DEVELOPMENT | 2003-05-20 | — | — | US | disclosed |
| US-20020137730-A1 | Positively charged non-natural amino acids, methods of making and using thereof in peptides | MEDICAL UNIVERSITY OF SOUTH CAROLINA | 2002-09-26 | — | — | US | disclosed |
| US-20020068701-A1 | Positively charged non-natural amino acids, methods of making thereof, and use thereof in peptides | MEDICAL UNIVERSITY OF SOUTH CAROLINA | 2002-06-06 | — | — | US | disclosed |
| US-6358922-B1 | ARGININE DERIVATIVES | MEDICAL UNIVERSITY OF SOUTH CAROLINA | 2002-03-19 | — | — | US | disclosed |
| WO-1998017626-A2 | POSITIVELY CHARGED NON-NATURAL AMINO ACIDS, METHODS OF MAKING THEREOF, AND USE THEREOF IN PEPTIDES | MEDICAL UNIVERSITY OF SOUTH CAROLINA (US) | 1998-04-30 | — | — | WO | disclosed |
| CN-1087624-A | Arginine derivative | WELLCOME FOUND (GB) | 1994-06-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068701-A1 | Positively charged non-natural amino acids, methods of making thereof, and use thereof in peptides | ARGLU1, NGLY1, QPCTL | NOS2 447/4885NOS3 322/4885NOS1 617/4885 |
| US-20020137730-A1 | Positively charged non-natural amino acids, methods of making and using thereof in peptides | NGLY1, LNPEP, DNPEP | NOS2 1906/4885NOS3 1450/4885NOS1 2372/4885 |
| US-20240400949-A1 | COMPOSITION, COMPOUND, RESIN, SUBSTRATE TREATMENT METHOD, AND MANUFACTURING METHOD FOR SEMICONDUCTOR DEVICE | RER1, POLG, PWWP2B | NOS2 215/4885NOS3 382/4885NOS1 179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.