Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6232549 | 0.72 | BPTF (0.49) | PFKFB3ALDH1A1MAPK14NPSR1SMN1; SMN2 | |
| SCHEMBL6370927 | 0.71 | PFKFB3 (0.45) | PFKFB3ALDH1A1MAPK14NPSR1SMN1; SMN2 | |
| SCHEMBL6604659 | 0.68 | PFKFB3 (0.52) | PFKFB3ALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL4047300 | 0.67 | ALDH1A1 (0.54) | PFKFB3ALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL6237378 | 0.66 | SMN1; SMN2 (0.69) | PFKFB3ALDH1A1MAPK14NPSR1SMN1; SMN2 | |
| Benzyl Bromide SCHEMBL7816396 | 0.63 | ALDH1A1 (0.49) | PFKFB3ALDH1A1NPSR1SMN1; SMN2LMNA | |
| SCHEMBL4178254 | 0.62 | ALDH1A1 (0.61) | PFKFB3ALDH1A1MAPK14NPSR1SMN1; SMN2 | |
| SCHEMBL6271937 | 0.62 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1NPSR1CYP3A4 | |
| SCHEMBL6232624 | 0.61 | MAPK14 (0.67) | PFKFB3ALDH1A1MAPK14HTTNPBWR1 | |
| SCHEMBL6378489 | 0.61 | NPBWR1 (0.54) | PFKFB3ALDH1A1MAPK14KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050256122-A1 | Substituted pyridazinones | PHARMACIA CORPORATION | 2005-11-17 | — | — | US | disclosed |
| US-20050020594-A1 | Substituted pyridazinones | PHARMACIA CORPORATION | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020594-A1 | Substituted pyridazinones | MAP4K2, MAPK6, MAP3K6 | PFKFB3 1287/4885ALDH1A1 2217/4885MAPK14 34/4885 |
| US-20050256122-A1 | Substituted pyridazinones | MAP4K2, MAPK6, MAP3K6 | PFKFB3 1287/4885ALDH1A1 2217/4885MAPK14 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.