Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6232549 | 0.77 | BPTF (0.49) | PFKFB3ALDH1A1MAPK14HTTKDM4E | |
| SCHEMBL6369775 | 0.77 | MAPK14 (0.59) | ALDH1A1MAPK14HTTKDM4ESMN1; SMN2 | |
| SCHEMBL6604659 | 0.73 | PFKFB3 (0.52) | PFKFB3ALDH1A1HTTKDM4ESMN1; SMN2 | |
| SCHEMBL4047300 | 0.72 | ALDH1A1 (0.54) | PFKFB3ALDH1A1HTTKDM4ESMN1; SMN2 | |
| SCHEMBL6370792 | 0.71 | PFKFB3 (0.41) | PFKFB3ALDH1A1MAPK14HTTKDM4E | |
| SCHEMBL6237378 | 0.71 | SMN1; SMN2 (0.69) | PFKFB3ALDH1A1MAPK14HTTKDM4E | |
| Benzyl Bromide SCHEMBL7816396 | 0.68 | ALDH1A1 (0.49) | PFKFB3ALDH1A1HTTKDM4ESMN1; SMN2 | |
| SCHEMBL4178254 | 0.67 | ALDH1A1 (0.61) | PFKFB3ALDH1A1MAPK14HTTKDM4E | |
| SCHEMBL6271937 | 0.67 | ALDH1A1 (0.50) | ALDH1A1HTTKDM4ESMN1; SMN2LMNA | |
| SCHEMBL7582089 | 0.66 | FPR2 (0.46) | ALDH1A1HTTLMNARAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050256122-A1 | Substituted pyridazinones | PHARMACIA CORPORATION | 2005-11-17 | — | — | US | disclosed |
| US-20050020594-A1 | Substituted pyridazinones | PHARMACIA CORPORATION | 2005-01-27 | — | — | US | disclosed |
| US-20040142932-A1 | Substituted pyridazinones | PHARMACIA CORPORATION | 2004-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142932-A1 | Substituted pyridazinones | MAP4K2, MAPK6, MAP3K6 | PFKFB3 1494/4885ALDH1A1 1889/4885MAPK14 29/4885 |
| US-20050020594-A1 | Substituted pyridazinones | MAP4K2, MAPK6, MAP3K6 | PFKFB3 1287/4885ALDH1A1 2217/4885MAPK14 34/4885 |
| US-20050256122-A1 | Substituted pyridazinones | MAP4K2, MAPK6, MAP3K6 | PFKFB3 1287/4885ALDH1A1 2217/4885MAPK14 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.