Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18128748 | 0.83 | LMNA (0.48) | APEX1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| Niacinamide SCHEMBL6371048 | 0.82 | APEX1 (0.71) | APEX1ALDH1A1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL18128755 | 0.81 | PKM (0.48) | APEX1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL10870623 | 0.78 | HDAC1 (0.48) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL18128752 | 0.74 | ALDH1A1 (0.42) | APEX1ALDH1A1SMN1; SMN2NPSR1LMNA | |
| SCHEMBL18128744 | 0.72 | PI4KA (0.46) | ALDH1A1SMN1; SMN2RAB9ALMNAIKBKE | |
| Niacinamide SCHEMBL8508206 | 0.72 | F7 (0.54) | APEX1ALDH1A1LMNA | |
| Niacinamide SCHEMBL8510793 | 0.71 | APEX1 (0.52) | APEX1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| Niacinamide SCHEMBL3281893 | 0.70 | ADORA2A (0.58) | APEX1ALDH1A1LMNAPKM | |
| SCHEMBL6524612 | 0.70 | RAB9A (0.64) | ALDH1A1SMN1; SMN2NPC1RAB9ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926340-B2 | NAD analogs and methods of using said NAD analogs in determining ribosylation of proteins with PARP mutants | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-03-27 | — | — | US | disclosed |
| US-20160299141-A1 | NAD ANALOGS AND METHODS OF USING SAID NAD ANALOGS IN DETERMINING RIBOSYLATION OF PROTEINS WITH PARP MUTANTS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2016-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160299141-A1 | NAD ANALOGS AND METHODS OF USING SAID NAD ANALOGS IN DETERMINING RIBOSYLATION OF PROTEINS WITH PARP MUTANTS | PARP11, PARP14, PARP15 | APEX1 70/4885ALDH1A1 1282/4885SMN1; SMN2 2766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.