Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.56 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GABRP | O00591 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL6227317 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL382027 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL382028 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL30947437 | 0.92 | LMNA (0.53) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL15346029 | 0.92 | TSHR (0.47) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL15346031 | 0.92 | TSHR (0.47) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL1398344 | 0.89 | TSHR (0.45) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL28453291 | 0.89 | TSHR (0.45) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL7903195 | 0.89 | TSHR (0.45) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL28265770 | 0.89 | TSHR (0.45) | TSHRTP53EGLN1EGLN3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0926299-B1 | Water-disintegratable cleaning sheet containing alkylcellulose | UNI CHARM CORP (JP) | 2008-11-12 | — | — | EP | claimed |
| EP-0926299-A2 | Water-disintegratable cleaning sheet containing alkylcellulose | UNI-CHARM CORPORATION (JP) | 1999-06-30 | — | — | EP | claimed |
| EP-0235961-A1 | Scratch inhibiting agent | LION CORPORATION (JP) | 1987-09-09 | — | — | EP | claimed |
| CN-107922739-A | Copolymers comprising polysiloxane macromonomer units, process for their preparation and their use in coating compositions and polymeric moulding compounds | 毕克化学有限公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-107189831-A | A kind of alcoholysis type ter-polymers diesel pour inhibitor and preparation method thereof | 上海应用技术大学 | 2017-09-22 | — | — | CN | disclosed |
| CN-105005183-A | Preparing method for styrene-acrylic resin/polyester resin compound type static charge image color matching agent | HUBEI DINGLONG CHEMICAL CO LTD | 2015-10-28 | — | — | CN | disclosed |
| US-8129026-B2 | (Meth)acrylate/aspartate amine curatives and coatings and articles comprising the same | PPG INDUSTRIES OHIO, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| US-20110206935-A1 | (METH)ACRYLATE/ASPARTATE AMINE CURATIVES AND COATINGS AND ARTICLES COMPRISING THE SAME | PPG INDUSTRIES OHIO, INC. (US) | 2011-08-25 | — | — | US | disclosed |
| US-7960495-B2 | polyurea comprising the reaction product of the acrylate/aspartate amine curative and isocyanate is also disclosed, as are coatings comprising such a polyurea and substrates coated with the same | PPG INDUSTRIES OHIO, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| EP-2099842-B1 | (METH)ACRYLATE/ASPARTATE AMINE CURATIVES AND COATINGS AND ARTICLES COMPRISING THE SAME | PPG IND OHIO INC (US) | 2011-03-30 | — | — | EP | disclosed |
| EP-1046747-B1 | Water-decomposable cleaning article and manufacturing method therefor | UNI CHARM CORP (JP) | 2010-11-03 | — | — | EP | disclosed |
| EP-1091042-A1 | Water-decomposable fibrous sheet, and method for producing it | UNI-CHARM CORPORATION (JP) | 2001-04-11 | — | — | EP | disclosed |
| EP-1046747-A1 | Water-decomposable cleaning article and manufacturing method therefor | UNI-CHARM CORPORATION (JP) | 2000-10-25 | — | — | EP | disclosed |
| CN-1267757-A | Hydrolytic adhesive-bonded cloth containing different fibre length regenerated cellulose fibre | UNI CHARM CORP (JP) | 2000-09-27 | — | — | CN | disclosed |
| EP-1024225-A1 | Fibrillated rayon-containing, water-decomposable fibrous sheet | UNI-CHARM CORPORATION (JP) | 2000-08-02 | — | — | EP | disclosed |
| EP-0945536-A2 | Method of manufacturing a water disintegratable non-woven fabric and the water disintegratable non-woven fabric | UNI-CHARM CORPORATION (JP) | 1999-09-29 | — | — | EP | disclosed |
| EP-0926299-A2 | Water-disintegratable cleaning sheet containing alkylcellulose | UNI-CHARM CORPORATION (JP) | 1999-06-30 | — | — | EP | disclosed |
| US-4761397-A | MULTILAYER SHEETS WITH POLYMER LATEX | FUJI PHOTO FILM CO., LTD. (JP) | 1988-08-02 | — | — | US | disclosed |
| EP-0063561-A1 | CROSS-LINKED HYDROPHILIC POLYMERS. | PATEL PRAVIN GORDHANBHAI (GB) | 1982-11-03 | — | — | EP | disclosed |
| WO-1982001553-A1 | CROSS-LINKED HYDROPHILIC POLYMERS | PATEL PRAVIN | 1982-05-13 | — | — | WO | disclosed |